Document Detail

Abdominal sonographic changes after antibody to tumor necrosis factor (anti-TNF) alpha therapy in Crohn's Disease.
MedLine Citation:
PMID:  19267199     Owner:  NLM     Status:  MEDLINE    
Prospective study carried out on 24 consecutive patients with Crohn's Disease, using sonography to assess changes caused by biological therapy and its relationship with the clinical-biological response. The Crohn's Disease Activity Index, the plasma concentration of C-reactive protein and abdominal sonograms (to assess the thickness and Doppler flow grade of the bowel wall and to detect the presence of any complications) were carried out one week prior to the induction treatment and two weeks after. The biological therapy induced remission or a partial response in 46% and 25% of the patients, respectively. It also caused a significant reduction in the thickness of the bowel wall (P = 0.005) and Doppler flow (P = 0.02), leading to the disappearance of complications in 50% of the patients. Sonographic changes were significantly more marked in patients who achieved some type of clinical-biological response, in such a way that sonograms were improved in 65% (P = 0.001) and complications disappeared in 100% of patients (P = 0.005) compared to those patients who did not respond to treatment. However, sonographic normality was only achieved in five out of 17 (29%) reactive patients (P = 0.27). This fact may support the use of sonography as a technique for optimizing the biological treatment of Crohn's Disease.
Jos? Mar?a Paredes; Tom?s Ripoll?s; Xavier Cort?s; Mar?a Jes?s Mart?nez; Mar?a Barrachina; Fernando G?mez; Eduardo Moreno-Osset
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-03-07
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  55     ISSN:  1573-2568     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-12     Completed Date:  2010-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  404-10     Citation Subset:  AIM; IM    
Servicio de Medicina Digestiva, Hospital Universitario Dr Peset, Gaspar Aguilar 90, Valencia 46017, Spain.
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MeSH Terms
Antibodies, Monoclonal / administration & dosage,  therapeutic use*
Crohn Disease / drug therapy,  physiopathology,  ultrasonography*
Dose-Response Relationship, Drug
Follow-Up Studies
Gastrointestinal Agents / administration & dosage,  therapeutic use*
Gastrointestinal Motility / physiology
Injections, Intravenous
Intestines / physiopathology,  ultrasonography
Middle Aged
Prospective Studies
Treatment Outcome
Tumor Necrosis Factor-alpha / antagonists & inhibitors*,  immunology
Ultrasonography, Doppler, Color / methods*
Young Adult
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Gastrointestinal Agents; 0/Tumor Necrosis Factor-alpha; 0/infliximab

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