Document Detail


Abdominal Hernia Repair With a Decellularized Dermal Scaffold Seeded With Autologous Bone-Marrow-Derived Mesenchymal Stem Cells.
MedLine Citation:
PMID:  21899574     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Surgeons usually use synthetic polymer meshes for abdominal wall hernia repair. However, synthetic polymer meshes exhibit a lack of growth and related complications. In this study, we produced a tissue-engineered patch for abdominal hernia repair. Autologous bone-marrow-derived mesenchymal stem cells (BMSCs) were isolated and proliferated in vitro; decellularized dermal scaffolds (DSs) were prepared using enzymatic process; and then BMSCs were seeded onto the DSs for the construction of tissue-engineered patches. Under general anesthesia, rabbits underwent creation of abdominal wall defects and which were repaired with BMSC-seeded DSs, acellular DSs, and skin sutures only, respectively. Animals were sacrificed after 2 months for assessing the histological and gross examination. Abdominal hernias were absent in animals repaired with cell-seeded group, and abdominal hernias or bulges appeared in all animals repaired with acellular group. All the animals that were not repaired died within 10 days. The cell-seeded implants were thicker and indicated good angiogenesis compared with that of the acellular implants, both in histological and gross examination. The tissue-engineered patches prepared with BMSCs seeding on DSs can be used for abdominal wall hernia repair.
Authors:
Yilin Zhao; Zhigang Zhang; Jinling Wang; Ping Yin; Jianyin Zhou; Maochuan Zhen; Wugeng Cui; Gang Xu; Donghai Yang; Zhongchen Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-7
Journal Detail:
Title:  Artificial organs     Volume:  -     ISSN:  1525-1594     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011, Copyright the Authors. Artificial Organs © 2011, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
Affiliation:
Department of Vascular Surgery, Zhongshan Hospital, Xiamen University Department of Emergency, Zhongshan Hospital, Xiamen University Department of Pathology, Zhongshan Hospital, Xiamen University Department of Hepatobiliary Surgery, Zhongshan Hospital, Xiamen University Department of Gastrointestinal Surgery, Zhongshan Hospital, Xiamen University, Xiamen Department of Orthopaedics Surgery, 208 Hospital of PLA, Changchun Medical School of Ningbo University, Ningbo, China.
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