| Abdominal fat from spine dual-energy x-ray absorptiometry and risk for subsequent diabetes. | |
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MedLine Citation:
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PMID: 20392865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Abdominal obesity is a major risk factor for diabetes. Dual-energy x-ray absorptiometry (DXA) of the lumbar spine provides an index of abdominal fat. OBJECTIVE: Our objective was to examine the hypothesis that DXA-derived abdominal fat measurement in women undergoing osteoporosis investigation predicts risk for subsequent diagnosis of diabetes. DESIGN: This historical cohort study was derived from the Manitoba Bone Density Program Database for the Province of Manitoba, Canada. SETTING AND PATIENTS: 30,252 nondiabetic women aged 40 yr and older were referred for baseline osteoporosis assessment with DXA between January 1990 and March 2007. MAIN OUTCOME MEASURES: Each woman's longitudinal provincial health service record was assessed for the presence of diabetes diagnosis codes after DXA testing. RESULTS: During 5.2 + or - 2.6 yr of observation, 1252 (4.1%) women met the case definition for diabetes. A greater proportion of abdominal fat from spine DXA was strongly related to subsequent diabetes diagnosis in models adjusted for age, body mass index, and other comorbidities. Those in the highest quintile had 3.56 (95% confidence interval = 2.67-4.75) times the risk for subsequent diabetes diagnosis compared with those in the lowest (reference) quintile. Fat from hip DXA was not predictive of subsequent diabetes after adjustment for the same variables (1.00, 95% confidence interval = 0.79-1.26). CONCLUSIONS: Predictive information about diabetes risk can be obtained from spine DXA scans performed for osteoporosis risk assessment. This is consistent with evidence linking abdominal fat with insulin resistance and the metabolic syndrome. |
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Authors:
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William D Leslie; Sora M Ludwig; Suzanne Morin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-14 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 3272-6 Citation Subset: AIM; IM |
Affiliation:
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University of Manitoba, Winnipeg, Canada R2H 2A6. bleslie@sbgh.mb.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adult Aged Aged, 80 and over Area Under Curve Body Composition Bone Density Canada Cohort Studies Diabetes Mellitus, Type 2 / complications, diagnosis* Female Health Surveys Humans Insulin Resistance Middle Aged Obesity, Abdominal / complications, diagnosis* Predictive Value of Tests Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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