Document Detail


Abdominal aortic aneurysm growth predicted by uptake of ultrasmall superparamagnetic particles of iron oxide: a pilot study.
MedLine Citation:
PMID:  21304070     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Abdominal aortic aneurysms are a major cause of death. Prediction of aneurysm expansion and rupture is challenging and currently relies on the simple measure of aneurysm diameter. Using MRI, we aimed to assess whether areas of cellular inflammation correlated with the rate of abdominal aortic aneurysm expansion.
METHODS AND RESULTS: Stable patients (n=29; 27 male; age, 70±5 years) with asymptomatic abdominal aortic aneurysms (4.0 to 6.6 cm) were recruited from a surveillance program and imaged using a 3-T MRI scanner before and 24 to 36 hours after administration of ultrasmall superparamagnetic particles of iron oxide (USPIO). The change in T2* value on T2*-weighted imaging was used to detect accumulation of USPIO within the abdominal aortic aneurysm. Histological examination of aneurysm tissue confirmed colocalization and uptake of USPIO in areas with macrophage infiltration. Patients with distinct mural uptake of USPIO had a 3-fold higher growth rate (n=11, 0.66 cm/y; P=0.020) than those with no (n=6, 0.22 cm/y) or nonspecific USPIO uptake (n=8, 0.24 cm/y) despite having similar aneurysm diameters (5.4±0.6, 5.1±0.5, and 5.0±0.5 cm, respectively; P>0.05). In 1 patient with an inflammatory aneurysm, there was a strong and widespread uptake of USPIO extending beyond the aortic wall.
CONCLUSIONS: Uptake of USPIO in abdominal aortic aneurysms identifies cellular inflammation and appears to distinguish those patients with more rapidly progressive abdominal aortic aneurysm expansion. This technique holds major promise as a new method of risk-stratifying patients with abdominal aortic aneurysms that extends beyond the simple anatomic measure of aneurysm diameter. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00794092.
Authors:
Jennifer M J Richards; Scott I Semple; Thomas J MacGillivray; Calum Gray; Jeremy P Langrish; Michelle Williams; Marc Dweck; William Wallace; Graham McKillop; Roderick T A Chalmers; O James Garden; David E Newby
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-08
Journal Detail:
Title:  Circulation. Cardiovascular imaging     Volume:  4     ISSN:  1942-0080     ISO Abbreviation:  Circ Cardiovasc Imaging     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-18     Completed Date:  2011-08-17     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101479935     Medline TA:  Circ Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  274-81     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00794092
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MeSH Terms
Descriptor/Qualifier:
Aged
Aortic Aneurysm, Abdominal / diagnosis*,  physiopathology
Contrast Media*
Dextrans / diagnostic use*
Female
Humans
Magnetic Resonance Imaging*
Magnetite Nanoparticles / diagnostic use*
Male
Pilot Projects
Grant Support
ID/Acronym/Agency:
FS/10/026/28209//British Heart Foundation; FS/11/14/28692//British Heart Foundation; G0701127//Medical Research Council; //British Heart Foundation
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Magnetite Nanoparticles; 0/ferumoxtran-10; K3R6ZDH4DU/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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