Document Detail


Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.
MedLine Citation:
PMID:  22055160     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1 × 10(-5)) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p < 1 × 10(-5)). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined p = 4.52 × 10(-10), odds ratio 1.15 [1.10-1.21]). No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. Gene-expression studies demonstrated a trend toward increased LRP1 expression for the rs1466535 CC genotype in arterial tissues; there was a significant (p = 0.029) 1.19-fold (1.04-1.36) increase in LRP1 expression in CC homozygotes compared to TT homozygotes in aortic adventitia. Functional studies demonstrated that rs1466535 might alter a SREBP-1 binding site and influence enhancer activity at the locus. In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression.
Authors:
Matthew J Bown; Gregory T Jones; Seamus C Harrison; Benjamin J Wright; Suzannah Bumpstead; Annette F Baas; Solveig Gretarsdottir; Stephen A Badger; Declan T Bradley; Kevin Burnand; Anne H Child; Rachel E Clough; Gillian Cockerill; Hany Hafez; D Julian A Scott; Simon Futers; Anne Johnson; Soroush Sohrabi; Alberto Smith; Matthew M Thompson; Frank M van Bockxmeer; Matthew Waltham; Stefan E Matthiasson; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Jan D Blankensteijn; Joep A W Teijink; Cisca Wijmenga; Jacqueline de Graaf; Lambertus A Kiemeney; Themistocles L Assimes; Ruth McPherson; ; ; ; ; Lasse Folkersen; Anders Franco-Cereceda; Jutta Palmen; Andrew J Smith; Nicolas Sylvius; John B Wild; Mette Refstrup; Sarah Edkins; Rhian Gwilliam; Sarah E Hunt; Simon Potter; Jes S Lindholt; Ruth Frikke-Schmidt; Anne Tybjærg-Hansen; Anne E Hughes; Jonathan Golledge; Paul E Norman; Andre van Rij; Janet T Powell; Per Eriksson; Kari Stefansson; John R Thompson; Steve E Humphries; Robert D Sayers; Panos Deloukas; Nilesh J Samani
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-04
Journal Detail:
Title:  American journal of human genetics     Volume:  89     ISSN:  1537-6605     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-14     Completed Date:  2012-02-21     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  619-27     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aorta / metabolism*
Aortic Aneurysm, Abdominal / genetics*
Case-Control Studies
Cell Line, Tumor
Data Interpretation, Statistical
Female
Follow-Up Studies
Genetic Loci / genetics*
Genetic Predisposition to Disease
Genome-Wide Association Study
Homozygote
Humans
Low Density Lipoprotein Receptor-Related Protein-1 / genetics*
Male
Odds Ratio
Organ Specificity
Polymorphism, Single Nucleotide*
Risk Factors
Sterol Regulatory Element Binding Protein 1 / genetics
Grant Support
ID/Acronym/Agency:
076113//Wellcome Trust; 084695//Wellcome Trust; 085475//Wellcome Trust; FS/11/16/28696//British Heart Foundation; PG/10/001/28098//British Heart Foundation; RG2008/08//British Heart Foundation
Chemical
Reg. No./Substance:
0/Low Density Lipoprotein Receptor-Related Protein-1; 0/SREBF1 protein, human; 0/Sterol Regulatory Element Binding Protein 1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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