Document Detail

Abdomen release in prone position does not improve oxygenation in an experimental model of acute lung injury.
MedLine Citation:
PMID:  11355127     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To analyze the effect of abdomen release in the prone position on oxygenation in an experimental model of acute lung injury. DESIGN: Experimental randomized controlled study. SETTING: Experimental laboratory of a tertiary university hospital. PARTICIPANTS: Mixed-breed adolescent pigs weighing between 25-31 kg. INTERVENTIONS: Thirty minutes after pulmonary edema was produced with oleic acid, the animals were turned prone and randomized into two groups: group I or control (n = 9), lying directly on the operating table; and group II (n = 11) with abdomen release, with positioning rolls under the upper part of the chest wall and the pelvis to allow free movement of the abdomen. MEASUREMENTS AND RESULTS: The gas exchange, respiratory mechanics, hemodynamics, intra-abdominal pressure (IAP) and the extravascular lung water (EVLW), determined by double indicator dilution method (DI), were recorded at baseline (time 0) and at 30, 60, 90, 120 and 150 min. The PaO2/FIO2 increased in both groups at 30 min after the pigs were placed in the prone position (time 60) and then decreased progressively until the end of the experimental period, with no statistical differences between the groups at any time (73.1 +/- 14.5 vs 79.5 +/- 14.9 at 150 min). Abdomen release was not associated with changes in the respiratory mechanics, EVLW or intra-abdominal pressure. CONCLUSIONS: Abdomen release in prone position does not improve oxygenation in an experimental model of acute lung injury.
M Colmenero-Ruiz; D Pola-Gallego de Guzmán; M M Jiménez-Quintana; E Fernández-Mondejar
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Intensive care medicine     Volume:  27     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-05-17     Completed Date:  2001-10-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  566-73     Citation Subset:  IM    
Department of Intensive Medicine, Virgen de las Nieves Hospital, Avenida de las Fuerzas Armadas 2, 18014 Granada, Spain.
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MeSH Terms
Blood Gas Analysis
Disease Models, Animal*
Extravascular Lung Water
Lung Compliance
Oleic Acid
Prone Position*
Pulmonary Edema / chemically induced,  metabolism,  physiopathology*,  therapy*
Pulmonary Gas Exchange
Random Allocation
Respiratory Distress Syndrome, Adult / chemically induced,  metabolism,  physiopathology*,  therapy*
Respiratory Mechanics
Treatment Outcome
Reg. No./Substance:
112-80-1/Oleic Acid

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