Document Detail


Abbreviated environmental enrichment enhances neurobehavioral recovery comparably to continuous exposure after traumatic brain injury.
MedLine Citation:
PMID:  21186330     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Environmental enrichment (EE) is a complex living milieu that has been shown to enhance functional recovery versus standard (STD) housing after experimental traumatic brain injury (TBI) and therefore may be considered a rodent correlate of rehabilitation. However, the typical EE paradigm consists of continuous exposure to enrichment after TBI, which is inconsistent with the limited time frame in clinical rehabilitation.
OBJECTIVE: To determine whether abbreviated EE (ie, rehabilitation-relevant dose response) confers benefits similar to typical EE after TBI.
METHODS: Adult male rats received either a controlled cortical impact (2.8 mm depth at 4 m/s) or sham injury and were then randomly assigned to TBI + EE, TBI + EE (2 hours), TBI + EE (4 hours), TBI + EE (6 hours), TBI + STD, and respective sham controls. Motor (beam balance/beam walk) and cognitive (Morris water maze) performance was assessed on postoperative days 1 to 5 and 14 to 19, respectively.
RESULTS: The TBI + EE (2 hours) and TBI + EE (4 hours) groups were not statistically different from the TBI + STD group in any behavioral assessment. In contrast, the TBI + EE (6 hours) group exhibited significant enhancement of motor and cognitive performance when compared with the TBI + STD group, as well as the TBI + EE (2 hours) and TBI + EE (4 hours) groups (P < .003), and did not differ from the TBI + EE (typical) group.
CONCLUSIONS: These data demonstrate that abbreviated EE (6 hours) produces motor and cognitive benefits similar to continuous EE after TBI and thus may be considered a dose-relevant rehabilitation paradigm.
Authors:
Benjamin Wells de Witt; Kathryn M Ehrenberg; Rose L McAloon; Amanda H Panos; Kaitlyn E Shaw; Priya V Raghavan; Elizabeth R Skidmore; Anthony E Kline
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-12-26
Journal Detail:
Title:  Neurorehabilitation and neural repair     Volume:  25     ISSN:  1552-6844     ISO Abbreviation:  Neurorehabil Neural Repair     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-03-31     Completed Date:  2012-03-07     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  100892086     Medline TA:  Neurorehabil Neural Repair     Country:  United States    
Other Details:
Languages:  eng     Pagination:  343-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Injuries / physiopathology,  rehabilitation*
Cognition Disorders / etiology,  physiopathology,  rehabilitation*
Disease Models, Animal
Environment, Controlled*
Gait Disorders, Neurologic / etiology,  physiopathology,  rehabilitation*
Male
Physical Therapy Modalities / standards*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
HD046700/HD/NICHD NIH HHS; K12 HD055931/HD/NICHD NIH HHS; NS060005/NS/NINDS NIH HHS; R01 HD046700-01A1/HD/NICHD NIH HHS; R01 HD046700-02/HD/NICHD NIH HHS; R01 HD046700-03/HD/NICHD NIH HHS; R01 HD046700-04/HD/NICHD NIH HHS; R01 HD069620/HD/NICHD NIH HHS; R01 NS060005-02/NS/NINDS NIH HHS; R01 NS060005-03/NS/NINDS NIH HHS; R01 NS060005-04/NS/NINDS NIH HHS
Comments/Corrections

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