| Abatacept therapy and safety management. | |
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MedLine Citation:
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PMID: 19560051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To elaborate a how-to-use abatacept material intended to help physicians in the management of patients with inflammatory diseases treated with this drug in routine practice. METHODS: 1) Selection of the relevant domains by a rheumatologists' panel; 2) Search for published evidence in each domain; 3) Elaboration of the clinical tool guide with a 3-level gradation of evidence (evidence-based medicine EBM, official recommendations and expert's opinion). The experts were 11 academic rheumatologists with a large experience in prescribing abatacept and in managing rheumatoid arthritis. They were all members of the CRI (Club Rhumatismes et Inflammation), a section of the French Rheumatology Society dedicated to the inflammatory rheumatic diseases. Each fact sheet was reviewed by two other experts; 4) Regular updating based on medical literature and postmarketing surveillance data. RESULTS: Four domains were considered relevant: abatacept contraindications, management of side effects or associated diseases appearing during abatacept treatment, management of "practical situations" such as surgery or pregnancy, physician and patient information. After the literature analysis and discussion during an experts' meeting, a consensus was reached on: a pre-treatment checklist aimed at searching abatacept contraindications; a what-to-do document when facing side effects or associated diseases (autoimmune pathology, bacterial or viral infections, cardiovascular diseases, intolerance to abatacept, solid or haematological malignancy) or "practical situations" (surgery, pregnancy, vaccination, travel, drug-drug interactions); an example of standard information letter to be addressed to the attending physician (rheumatologist and general practitioner); an example of standard information letter to be addressed to the patient. CONCLUSION: Based on both an EBM approach and an expert's opinion approach, this abatacept clinical tool guide should provide assistance to all physicians attending patients treated with abatacept. For a better implementation in clinical practice, this tool guide will be available online at www.cri-net.com and regularly updated. |
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Authors:
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Thao Pham; Pascal Claudepierre; Arnaud Constantin; Bruno Fautrel; Laure Gossec; Jacques-Eric Gottenberg; Philippe Goupille; Eric Hachulla; Charles Masson; Jacques Morel; Alain Saraux; Thierry Schaeverbeke; Daniel Wendling; Xavier Mariette; Jean Sibilia |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Joint, bone, spine : revue du rhumatisme Volume: 76 Suppl 1 ISSN: 1778-7254 ISO Abbreviation: Joint Bone Spine Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-06-29 Completed Date: 2009-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100938016 Medline TA: Joint Bone Spine Country: France |
Other Details:
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Languages: eng Pagination: S3-S55 Citation Subset: IM |
Affiliation:
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Service de Rhumatologie, CHU Conception, Marseille, France. thao.pham@mail.ap-hm.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antirheumatic Agents
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adverse effects,
therapeutic use* Arthritis, Rheumatoid / drug therapy* Humans Immunoconjugates / adverse effects, therapeutic use* Safety Management / methods* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents; 0/Immunoconjugates; 0/abatacept |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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