Document Detail


Abatacept in psoriatic arthritis: Case report and short review.
MedLine Citation:
PMID:  24347977     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting about 6-10% of patients with cutaneous psoriasis. According to current knowledge, activated T-cells seem to play a pivotal role in the pathogenesis of both psoriasis and PsA. Abatacept is a novel biologic agent selectively designed to interfere with T-cells co-stimulation. Structurally, it is a soluble, fully human fusion protein consisting of the extracellular domain of CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) linked to a modified Fc portion of human IgG1. Abatacept is now approved as a first-line treatment for rheumatoid arthritis (RA), but preliminary data disclose a potential role of abatacept in the treatment of other autoimmune diseases. In this article, we report a case of successful treatment with abatacept of a psoriatic arthritis patients who developed adverse drug reactions (ADRs) to medication commonly used in PsA, including three different anti-TNF-α agents. In addition, we review the scientific evidences supporting a possible role of abatacept in treatment of patients with psoriasis and PsA and the paradox of abatacept-induced psoriasis.
Authors:
Francesco Ursini; Saverio Naty; Emilio Russo; Rosa Daniela Grembiale
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacology & pharmacotherapeutics     Volume:  4     ISSN:  0976-500X     ISO Abbreviation:  J Pharmacol Pharmacother     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-18     Completed Date:  2013-12-18     Revised Date:  2014-01-13    
Medline Journal Info:
Nlm Unique ID:  101552113     Medline TA:  J Pharmacol Pharmacother     Country:  India    
Other Details:
Languages:  eng     Pagination:  S29-32     Citation Subset:  -    
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