Document Detail

Abacavir and Lamivudine Exposures during Pregnancy and Non-Defect Adverse Pregnancy Outcomes: Data from the Antiretroviral Pregnancy Registry.
MedLine Citation:
PMID:  25469525     Owner:  NLM     Status:  Publisher    
BACKGROUND:: The Antiretroviral Pregnancy Registry (APR), an international, voluntary registry, provides information on teratogenicity and non-defect adverse pregnancy outcomes.
METHODS:: We analyzed APR prospective singleton pregnancies, estimating frequencies of and risk for non-defect adverse outcomes among HIV-infected women. Prenatal exposures to abacavir (ABC)-containing regimens versus non-ABC antiretroviral (ARV) regimens, and lamivudine (3TC)-containing regimens versus non-3TC regimens were compared.
RESULTS:: Of 2,006 outcomes with prenatal ABC exposure, 95.6% were live births; 4.4% were spontaneous/induced abortions and stillbirths. Of live births, 16.2% had low birth weight (LBW); 11.9% were preterm births. Relative risks (RR) comparing exposure to ABC versus non-ABC ARV regimens were: spontaneous abortions 0.92 (95% CI: 0.66-1.27); induced abortions 0.84 (95% CI: 0.59-1.21); stillbirths 0.59 (95% CI: 0.35-1.00); preterm births 0.96 (95% CI: 0.84-1.09); LBW 1.00 (95% CI: 0.90-1.13).Of 11,211 outcomes with prenatal 3TC exposure, 95.3% were live births; 4.7% were spontaneous/induced abortions and stillbirths. Of live births, 16.2% had LBW; 11.9% were preterm births. The RRs comparing exposure to 3TC versus non-3TC ARV regimens were: spontaneous abortions 0.63 (95% CI: 0.50-0.80); induced abortions 0.54 (95% CI: 0.43-0.69); stillbirths 1.25 (95% CI: 0.86-1.80); preterm births 0.86 (95% CI: 0.77-0.95); LBW 1.02 (95% CI: 0.93-1.12).
CONCLUSIONS:: ABC-containing and non-ABC ARV regimens have similar risks for non-birth defect adve rse pregnancy outcomes. 3TC-containing regimens have lower risk for spontaneous abortions, induced abortions and preterm births compared to non-3TC ARV regimens, while both regimens had similar prevalence and risks for stillbirths and LBW.
Vani Vannappagari; Nana Koram; Jessica Albano; Hugh Tilson; Conway Gee
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-2
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  -     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-3     Completed Date:  -     Revised Date:  2014-12-4    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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