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Aaptamine Derivatives from the Indonesian Sponge Aaptos suberitoides.
MedLine Citation:
PMID:  23282083     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Four new aaptamine derivatives (1-4) along with aaptamine (5) and three related compounds (6-8) were isolated from the ethanol extract of the sponge Aaptos suberitoides collected in Indonesia. The structures of the new compounds were unambiguously determined by one- and two-dimensional NMR and by HRESIMS measurements. Compounds 3, 5, and 6 showed cytotoxic activity against the murine lymphoma L5178Y cell line, with IC(50) values ranging from 0.9 to 8.3 μM.
Authors:
Cong-Dat Pham; Rudolf Hartmann; Werner E G Müller; Nicole de Voogd; Daowan Lai; Peter Proksch
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-2
Journal Detail:
Title:  Journal of natural products     Volume:  -     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University , Universitaetsstrasse 1, 40225 Duesseldorf, Germany.
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