| The Aachen miniaturized heart-lung machine--first results in a small animal model. | |
| | |
MedLine Citation:
|
PMID: 19874283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Congenital heart surgery most often incorporates extracorporeal circulation. Due to foreign surface contact and the administration of foreign blood in many children, inflammatory response and hemolysis are important matters of debate. This is particularly an issue in premature and low birth-weight newborns. Taking these considerations into account, the Aachen miniaturized heart-lung machine (MiniHLM) with a total static priming volume of 102 mL (including tubing) was developed and tested in a small animal model. Fourteen female Chinchilla Bastard rabbits were operated on using two different kinds of circuits. In eight animals, a conventional HLM with Dideco Kids oxygenator and St?ckert roller pump (Sorin group, Milan, Italy) was used, and the Aachen MiniHLM was employed in six animals. Outcome parameters were hemolysis and blood gas analysis including lactate. The rabbits were anesthetized, and a standard median sternotomy was performed. The ascending aorta and the right atrium were cannulated. After initiating cardiopulmonary bypass, the aorta was cross-clamped, and cardiac arrest was induced by blood cardioplegia. Blood samples for hemolysis and blood gas analysis were drawn before, during, and after cardiopulmonary bypass. After 1 h aortic clamp time, all animals were weaned from cardiopulmonary bypass. Blood gas analysis revealed adequate oxygenation and perfusion during cardiopulmonary bypass, irrespective of the employed perfusion system. The use of the Aachen MiniHLM resulted in a statistically significant reduced decrease in fibrinogen during cardiopulmonary bypass. A trend revealing a reduced increase in free hemoglobin during bypass in the MiniHLM group could also be observed. This newly developed Aachen MiniHLM with low priming volume, reduced hemolysis, and excellent gas transfer (O(2) and CO(2)) may reduce circuit-induced complications during heart surgery in neonates. |
| | |
Authors:
|
Heike Schnoering; Jutta Arens; Joerg S Sachweh; Melanie Veerman; Rene Tolba; Thomas Schmitz-Rode; Ulrich Steinseifer; Jaime F Vazquez-Jimenez |
Related Documents
:
|
16322733 - Technique and results for integration of the quest mps all-blood cardioplegia delivery ... 119053 - Alteration in the distribution of organ perfusion following profound hypothermia and ci... 21092063 - Immune surveillance of the normal human cns takes place in dependence of the locoregion... |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-28 |
Journal Detail:
|
Title: Artificial organs Volume: 33 ISSN: 1525-1594 ISO Abbreviation: Artif Organs Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-12-21 Completed Date: 2010-03-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
|
Languages: eng Pagination: 935-40 Citation Subset: IM |
Affiliation:
|
Pediatric Cardiac Surgery, Medical Faculty, RWTH Aachen University, Aachen, Germany. hschnoering@ukaachen.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Gas Analysis Cardiopulmonary Bypass / instrumentation* Equipment Design Female Heart-Lung Machine* Hemodynamics Hemolysis Humans Models, Animal Pediatrics / instrumentation* Rabbits |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Management of Deep Wound Complications With Vacuum-Assisted Therapy After Berlin Heart EXCOR Ventric...
Next Document: Comparison of Two Types of Neonatal Extracorporeal Life Support Systems With Pulsatile and Nonpulsat...