Document Detail


AVP response to LBNP is attenuated in a hyperbaric environment.
MedLine Citation:
PMID:  16110689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Accumulated evidence indicates attenuated vasopressin (AVP) release associated with hyperbaria in humans. The present study was designed to test the hypothesis that plasma AVP response to central hypovolemia was attenuated in a hyperbaric environment. METHODS: Response of AVP to central hypovolemic stress, in the form of lower-body negative pressure (LBNP), was measured in 10 men at 1 and 3 atmosphere absolute (ATA) air. The stress consisted of 4 min each of control and LBNP at -20 and -40 mmHg. Plasma AVP, plasma norepinephrine (NE), plasma osmolality, and hematocrit (Hct) were measured. Thoracic impedance (Z0), and leg volume were also determined. RESULTS: The baseline AVP (0.9 +/- 0.3 pg x ml(-1)) at 1 ATA increased significantly in response to -40 mmHg LBNP (1.8 +/- 0.6 pg x ml(-1)), but the increase was attenuated at 3 ATA (1.2 +/- 0.8 pg x ml(-1)). The baseline NE at 3 ATA was lower by 22.4 pg x ml(-1) than that of 1 ATA (226.5 pg x ml(-1)). NE increased with increasing LBNP at both environmental pressures, but the increase was independent of the pressure. Changes in Z0, reflecting thoracic blood volume, were identical in both environments. Mean arterial pressure, plasma osmolality, and Hct remained constant throughout the experimental period. Leg volume increased stress dependently during LBNP (approximately 34 ml at -20 mmHg; approximately 74 ml at -40 mmHg) and the increment was similar in the two environments. CONCLUSION: The present study revealed that hyperbaria attenuated the response of AVP and NE to hypovolemic stress. The attenuated AVP response to LBNP was associated with neither plasma osmolality nor intrathoracic blood shift.
Authors:
Sueko Sagawa; Katsuya Yamauchi; Yuka Tsutsui; Yutaka Endo; Keizo Shiraki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  76     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-22     Completed Date:  2005-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  739-43     Citation Subset:  IM; S    
Affiliation:
Department of Sports Life Style Management, National Institute of Fitness and Sports, Kanoya, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Atmospheric Pressure*
Hematocrit
Humans
Hypovolemia / physiopathology*
Male
Norepinephrine / blood
Pressoreceptors / physiology
Regional Blood Flow
Thorax / blood supply
Vasopressins / blood*,  secretion*
Chemical
Reg. No./Substance:
11000-17-2/Vasopressins; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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