| AV119, a Natural Sugar from Avocado gratissima, Modulates the LPS-Induced Proinflammatory Response in Human Keratinocytes. | |
| | |
MedLine Citation:
|
PMID: 20936426 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Keratinocytes play an active role in innate immune responses by secreting a variety of cytokines and chemokines. The release of critical proinflammatory cytokines, which are necessary to activate the immune response, is induced by the stimulation of Toll-like receptors (TLRs) by molecules present on pathogenic micro-organisms such as lipopolysaccharide (LPS). AV119, a patented blend of avocado sugars, induced the aggregation of Malassezia furfur, a dimorphic, lipid-dependent yeast that is part of the normal human cutaneous commensal flora and inhibited its penetration into the keratinocytes. In the present study, the anti-inflammatory effects of AV119 were investigated in LPS-induced inflammation of human keratinocytes. In particular, we analysed the modulation of the LPS-induced expression of proinflammatory cytokines and heat shock protein 70 (HSP70) by AV119 and the involvement of TLR-4. Our data show that AV119 is able to modulate significantly the proinflammatory response in human keratinocytes, blocking the NF-kB activation in human keratinocytes. |
| | |
Authors:
|
Giovanna Donnarumma; Iole Paoletti; Elisabetta Buommino; Alessandra Fusco; Caroline Baudouin; Philippe Msika; Maria Antonietta Tufano; Adone Baroni |
Related Documents
:
|
15522916 - New insights into the molecular mechanism of interleukin-10-mediated immunosuppression. 20200406 - Differential effects of selective hdac inhibitors on macrophage inflammatory responses ... 20148136 - Signaling pathways involved in lps induced tnfalpha production in human adipocytes. 11521066 - The lipemia of sepsis: triglyceride-rich lipoproteins as agents of innate immunity. 19752226 - Regulatory t cells negatively regulate neovasculature of airway remodeling via dll4-not... 21956656 - Identification of biomarkers for tuberculosis disease using a novel dual-color rt-mlpa ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Inflammation Volume: 34 ISSN: 1573-2576 ISO Abbreviation: Inflammation Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7600105 Medline TA: Inflammation Country: United States |
Other Details:
|
Languages: eng Pagination: 568-75 Citation Subset: IM |
Affiliation:
|
Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Second University of Naples, Naples, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A tailored approach to family-centered genetic counseling for cystic fibrosis newborn screening: the...
Next Document: Lichen recolonisation in an urban-industrial area of southern Poland as a result of air quality impr...