Document Detail


ATR-FTIR as a thickness measurement technique for hydrated polymer-on-polymer coatings.
MedLine Citation:
PMID:  19582857     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hydrated polymer coatings on polymer substrates are common for many biomedical applications, such as tissue engineering constructs, contact lenses, and catheters. The thickness of the coatings can affect the mechanical behavior of the systems and the cellular response, but measuring the coating thickness can be quite challenging using conventional methods. We propose a new method, that is, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) to determine the relative thickness, combined with atomic force microscopy to calibrate the ATR-FTIR measurements. This technique was successfully employed to determine the hydrated thickness of a series of crosslinked tetraglyme coatings on ultrahigh molecular weight polyethylene substrates intended to reduce wear of acetabular cups in total hip replacements. The hydrated coatings ranged from 30 to 200 nm thick and were accurately measured despite the relatively high root-mean-square (RMS) roughness of the substrates, 20-35 nm (peak-to-peak roughness 55-100 nm). The calibrated ATR-FTIR technique is a promising new method for measuring the thickness of many other polymer-on-polymer and hydrated coatings.
Authors:
Sheryl R Kane; Paul D Ashby; Lisa A Pruitt
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  91     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-07     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  United States    
Other Details:
Languages:  eng     Pagination:  613-20     Citation Subset:  IM    
Affiliation:
Joint Graduate Group in Bioengineering, UC San Francisco, Berkeley, California 94720, USA.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Calibration
Coated Materials, Biocompatible*
Cross-Linking Reagents
Image Processing, Computer-Assisted
Materials Testing / methods*
Molecular Weight
Polyethylene Glycols
Polyethylenes
Polymers
Spectrometry, X-Ray Emission
Spectroscopy, Fourier Transform Infrared
Grant Support
ID/Acronym/Agency:
EB-002027/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Coated Materials, Biocompatible; 0/Cross-Linking Reagents; 0/Polyethylene Glycols; 0/Polyethylenes; 0/Polymers; 0/ultra-high molecular weight polyethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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