Document Detail


The ATPase subunit 6 gene sequence predicts that RNA editing is conserved between lizard- and human-infecting Leishmania.
MedLine Citation:
PMID:  10415335     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Here we investigate the similarities in the kinetoplastid RNA editing process between human- and lizard-infecting Leishmania species. We present the sequence of the maxicircle-encoded ATPase subunit 6 gene from L. (V.) panamensis, L. (L.) mexicana and L. (L.) donovani species of human-infecting Leishmania. These represent the first available sequences of this gene from Leishmania species other than the lizard-infecting L. tarentolae. The gene sequences are highly conserved, both over the edited and unedited parts of the gene, implying that the RNA editing process is likely to be highly conserved between Leishmania species. Indeed, the first editing domain is absolutely conserved in all three Leishmania species studied and L. tarentolae. A phylogeny based on part of the ATPase subunit 6 gene placed the lizard-infecting Leishmania within the monophyletic Leishmania genus, supporting previous data which suggest that lizard- and human-infecting Leishmania species are closely related.
Authors:
S Brewster; D C Barker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gene     Volume:  235     ISSN:  0378-1119     ISO Abbreviation:  Gene     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-09     Completed Date:  1999-09-09     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  77-84     Citation Subset:  IM    
Affiliation:
Molteno Outstation of NIMR, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF118635;  AF118655
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphatases / chemistry,  genetics*
Amino Acid Sequence
Animals
Base Sequence
Consensus Sequence / genetics
Conserved Sequence / genetics
Cytochrome b Group / genetics
DNA, Kinetoplast / genetics
Evolution, Molecular*
Genes, Protozoan / genetics
Genetic Variation / genetics
Humans
Leishmania / classification,  enzymology,  genetics*
Lizards / parasitology*
Molecular Sequence Data
Phylogeny
RNA Editing / genetics*
RNA, Messenger / chemistry,  genetics
Sequence Alignment
Trypanosoma / genetics
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Cytochrome b Group; 0/DNA, Kinetoplast; 0/RNA, Messenger; EC 3.6.1.-/Adenosine Triphosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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