Document Detail

ATPase may play a critical role in disturbance of energy metabolism in congestive heart failure rats.
MedLine Citation:
PMID:  25419414     Owner:  NLM     Status:  Publisher    
OBJECTIVE: This study aims to explore the expression and significance of ATPase in myocardium of congestive heart failure induced by pressure overload in rats.
METHODS: Male SD rats were divided into 3 groups randomly: Control group (C group), coarctation of abdominal aorta 15 weeks group (A group) and sham operation group (SH group). The hemodynamics parameters were measured. The size of adenine acid pool (ATP, ADP) in myocardium was measured by high performance liquid chromatography (HPLC). The mRNA copies of ATPase-α subunit, ATPase-6 subunit in ventricular myocardium were determined by RT-PCR. The protein content of F1-ATPase in mitochondria was detected by Western blot analysis.
RESULTS: The ±dp/dtmax and contents of ATP and ADP decreased significantly in myocardium were decreased in A group. Compared with C and SH group, the mRNA copies of ATPase-α subunit, ATPase-6 subunit and the protein content of F1-ATPase were decreased in A group.
CONCLUSION: The expression of F1-ATPase decreased parallel with abnormal of the adenine nucleotide in myocardium of congestive heart failure. It may play a critical role in disturbance of energy metabolism in disfunction of heart.
Rong Song; Shanjun Zhu; Hongming Zhang; Xiaoyan Li; Songlin Wu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-15
Journal Detail:
Title:  International journal of clinical and experimental medicine     Volume:  7     ISSN:  1940-5901     ISO Abbreviation:  Int J Clin Exp Med     Publication Date:  2014  
Date Detail:
Created Date:  2014-11-24     Completed Date:  -     Revised Date:  2014-11-25    
Medline Journal Info:
Nlm Unique ID:  101471010     Medline TA:  Int J Clin Exp Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  3654-3658     Citation Subset:  -    
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