Document Detail


H+/K+-ATPase inhibitors: a patent review.
MedLine Citation:
PMID:  23205582     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: H(+)/K(+)-ATPase is a P-type ATP-driven cation transporter which exchanges ions (protons, chloride ions, and potassium ions) across the cell membrane. Modulators of H(+)/K(+)-ATPase affect H(+)/K(+) exchange.
AREAS COVERED: This article describes various H(+)/K(+)-ATPase inhibitors of biological importance in clinical studies and drug development for gastric acid-related diseases and gastrointestinal disorders.
EXPERT OPINION: H(+)/K(+)-ATPase modulators have attracted much interest for their clinical implication in gastric acid-related diseases. Future studies of gastric H(+)/K(+)-ATPase inhibitors may focus on the correlation of pharmacogenetics and pharmacogenomics with the gastric acid secretion and development of more effective H(+)/K(+)-ATPase inhibitors to increase their residence time such as tenatoprazole and novel chemical-mediated absorption chemicals. The K(+)-competitive acid pump antagonists (APAs) are invented and independent of an acidic environment with better inhibition of the pump rapidly control acid secretion with a larger extent. The most innovative and promising compounds of APAs is AZD-0865, which is a modification of SCH28080. H(+)/K(+)-ATPase inhibitors can be tried to treat other diseases, especially viral infection after numerous clinical trials, and respiratory disease.
Authors:
Hao Li; Ling Meng; Fei Liu; Ji-Fu Wei; Yong-Qing Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-12-04
Journal Detail:
Title:  Expert opinion on therapeutic patents     Volume:  23     ISSN:  1744-7674     ISO Abbreviation:  Expert Opin Ther Pat     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-19     Completed Date:  2013-06-04     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9516419     Medline TA:  Expert Opin Ther Pat     Country:  England    
Other Details:
Languages:  eng     Pagination:  99-111     Citation Subset:  IM    
Affiliation:
Research Division of Clinical Pharmacology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Clinical Trials as Topic
Drug Design*
Enzyme Inhibitors / pharmacology*
Gastric Acid / metabolism
Gastrointestinal Diseases / drug therapy,  physiopathology
H(+)-K(+)-Exchanging ATPase / antagonists & inhibitors*
Humans
Imidazoles / pharmacology
Patents as Topic
Pharmacogenetics
Pyridines / pharmacology
Chemical
Reg. No./Substance:
0/AZD0865; 0/Enzyme Inhibitors; 0/Imidazoles; 0/Pyridines; EC 3.6.1.10/H(+)-K(+)-Exchanging ATPase

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