Document Detail

An ATP-sensitive potassium (KATP) channel opener, nicorandil, lowers the threshold for ischemic preconditioning in barbital-anesthetized dogs.
MedLine Citation:
PMID:  9476575     Owner:  NLM     Status:  MEDLINE    
To determine whether the adenosine triphosphate (ATP)-sensitive potassium channel (KATP channel) opener, nicorandil, lowers the threshold for the infarct-reducing effect of preconditioning (PC), barbital-anesthetized dogs were subjected to 60-min occlusion (60'OC) of left anterior descending coronary artery (LAD) followed by 3-h reperfusion (3h-RP). At the end of the 3h-RP, heart was resected to measure infarct size. Infarct size was determined by triphenyltetrazolium chloride (TTC) staining, calculated gravimetrically and was expressed as a percent age of area at risk (AAR). Myocardial blood flow was measured by radioactive microspheres. Single 5-min LAD occlusion 10 min before 60'OC (5'PC group) markedly reduced infarct size, compared to the controls (11.8 +/- 3.7% versus 26.8 +/- 4.7%; P < 0.05). Neither 2.5-min PC (2.5'PC group), nor 2.5-min intracoronary infusion with 0.5 microgram/kg per min of nicorandil followed by a 10-min drug-free period (2.5'NC group), showed a cardioprotective effect (26.5 +/- 1.7% and 20.7 +/- 2.8%, respectively). However, when nicorandil was administered during the 2.5-min LAD occlusion period (2.5'PC + 2.5'NC group), infarct size was significantly reduced to an extent similar to that in 5'PC group (13.6 +/- 1.2%). There were no significant differences in hemodynamics, collateral circulation, or AAR between groups. These results suggest that nicorandil lowers the threshold for the infarct-reducing effect of PC in dogs by, at least in part, activation of myocardial KATP channels.
T Mizumura; S Saito; Y Ozawa; K Kanmatsuse; G J Gross
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart and vessels     Volume:  Suppl 12     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  1997  
Date Detail:
Created Date:  1998-04-07     Completed Date:  1998-04-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  175-7     Citation Subset:  IM    
Second Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Heart / drug effects*
Ischemic Preconditioning, Myocardial* / methods
Niacinamide / analogs & derivatives*,  pharmacology
Potassium Channels / agonists*
Regional Blood Flow / drug effects
Time Factors
Reg. No./Substance:
0/Potassium Channels; 57-44-3/Barbital; 65141-46-0/Nicorandil; 98-92-0/Niacinamide

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