| An ATP-sensitive potassium (KATP) channel opener, nicorandil, lowers the threshold for ischemic preconditioning in barbital-anesthetized dogs. | |
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MedLine Citation:
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PMID: 9476575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine whether the adenosine triphosphate (ATP)-sensitive potassium channel (KATP channel) opener, nicorandil, lowers the threshold for the infarct-reducing effect of preconditioning (PC), barbital-anesthetized dogs were subjected to 60-min occlusion (60'OC) of left anterior descending coronary artery (LAD) followed by 3-h reperfusion (3h-RP). At the end of the 3h-RP, heart was resected to measure infarct size. Infarct size was determined by triphenyltetrazolium chloride (TTC) staining, calculated gravimetrically and was expressed as a percent age of area at risk (AAR). Myocardial blood flow was measured by radioactive microspheres. Single 5-min LAD occlusion 10 min before 60'OC (5'PC group) markedly reduced infarct size, compared to the controls (11.8 +/- 3.7% versus 26.8 +/- 4.7%; P < 0.05). Neither 2.5-min PC (2.5'PC group), nor 2.5-min intracoronary infusion with 0.5 microgram/kg per min of nicorandil followed by a 10-min drug-free period (2.5'NC group), showed a cardioprotective effect (26.5 +/- 1.7% and 20.7 +/- 2.8%, respectively). However, when nicorandil was administered during the 2.5-min LAD occlusion period (2.5'PC + 2.5'NC group), infarct size was significantly reduced to an extent similar to that in 5'PC group (13.6 +/- 1.2%). There were no significant differences in hemodynamics, collateral circulation, or AAR between groups. These results suggest that nicorandil lowers the threshold for the infarct-reducing effect of PC in dogs by, at least in part, activation of myocardial KATP channels. |
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Authors:
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T Mizumura; S Saito; Y Ozawa; K Kanmatsuse; G J Gross |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Heart and vessels Volume: Suppl 12 ISSN: 0910-8327 ISO Abbreviation: Heart Vessels Publication Date: 1997 |
Date Detail:
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Created Date: 1998-04-07 Completed Date: 1998-04-07 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: JAPAN |
Other Details:
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Languages: eng Pagination: 175-7 Citation Subset: IM |
Affiliation:
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Second Department of Medicine, Nihon University School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Barbital Dogs Female Heart / drug effects* Ischemic Preconditioning, Myocardial* / methods Male Niacinamide / analogs & derivatives*, pharmacology Nicorandil Potassium Channels / agonists* Regional Blood Flow / drug effects Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels; 57-44-3/Barbital; 65141-46-0/Nicorandil; 98-92-0/Niacinamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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