| ATP-loaded liposomes for treatment of myocardial ischemia. | |
| | |
MedLine Citation:
|
PMID: 20049815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A major obstacle to drug therapy for treatment of potential myocardial infarction is the limited access to the ischemic myocardium by drugs in an active form. Encouraging results have been reported with liposomes loaded with ATP in a variety of in vitro and in vivo models. We describe methods for optimized encapsulation of ATP in liposomes, enhancement of their effectiveness by increasing circulation time, and targeting of injured myocardial cells with surface attached antimyosin. In isolated ischemic rat hearts, ATP-loaded liposomes and ATP-loaded immunoliposomes effectively protected myocardium from ischemia/reperfusion damage as measured by systolic and diastolic functional improvements. In vivo, in rabbits with induced localized myocardial ischemia, liposomal encapsulation of ATP significantly diminished the proportion of ventricular muscle at risk that was irreversibly damaged during reperfusion. Therefore, ATP encapsulated in liposomes can provide an effective exogenous source for in vivo application which can protect ischemically damaged hearts. |
| | |
Authors:
|
William C Hartner; Daya D Verma; Tatyana S Levchenko; Eugene A Bernstein; Vladimir P Torchilin |
Related Documents
:
|
11709405 - Blocking na(+)/h(+) exchange reduces [na(+)](i) and [ca(2+)](i) load after ischemia and... 20565865 - Dietary red palm oil supplementation reduces myocardial infarct size in an isolated per... 16961725 - Role of adenosine as adjunctive therapy in acute myocardial infarction. 7532745 - Contraction band necrosis: its modification by the free radical scavenger n-2-mercaptop... 7521045 - Radiofrequency catheter ablation of the atrioventricular junction by a supravalvular no... 15053185 - Ventricular assist devices as destination therapy. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Volume: 1 ISSN: 1939-0041 ISO Abbreviation: Wiley Interdiscip Rev Nanomed Nanobiotechnol Publication Date: 2009 Sep-Oct |
Date Detail:
|
Created Date: 2010-01-05 Completed Date: 2010-03-11 Revised Date: 2011-01-14 |
Medline Journal Info:
|
Nlm Unique ID: 101508311 Medline TA: Wiley Interdiscip Rev Nanomed Nanobiotechnol Country: United States |
Other Details:
|
Languages: eng Pagination: 530-9 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2009 John Wiley & Sons, Inc. |
Affiliation:
|
Departmentof Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Triphosphate
/
administration & dosage*,
chemistry Animals Drug Delivery Systems / methods* Humans Liposomes / administration & dosage*, chemistry Myocardial Ischemia / drug therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Liposomes; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned f...
Next Document: Nanotechnology in joint replacement.