Document Detail

ATP-loaded liposomes for treatment of myocardial ischemia.
MedLine Citation:
PMID:  20049815     Owner:  NLM     Status:  MEDLINE    
A major obstacle to drug therapy for treatment of potential myocardial infarction is the limited access to the ischemic myocardium by drugs in an active form. Encouraging results have been reported with liposomes loaded with ATP in a variety of in vitro and in vivo models. We describe methods for optimized encapsulation of ATP in liposomes, enhancement of their effectiveness by increasing circulation time, and targeting of injured myocardial cells with surface attached antimyosin. In isolated ischemic rat hearts, ATP-loaded liposomes and ATP-loaded immunoliposomes effectively protected myocardium from ischemia/reperfusion damage as measured by systolic and diastolic functional improvements. In vivo, in rabbits with induced localized myocardial ischemia, liposomal encapsulation of ATP significantly diminished the proportion of ventricular muscle at risk that was irreversibly damaged during reperfusion. Therefore, ATP encapsulated in liposomes can provide an effective exogenous source for in vivo application which can protect ischemically damaged hearts.
William C Hartner; Daya D Verma; Tatyana S Levchenko; Eugene A Bernstein; Vladimir P Torchilin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology     Volume:  1     ISSN:  1939-0041     ISO Abbreviation:  Wiley Interdiscip Rev Nanomed Nanobiotechnol     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2010-01-05     Completed Date:  2010-03-11     Revised Date:  2011-01-14    
Medline Journal Info:
Nlm Unique ID:  101508311     Medline TA:  Wiley Interdiscip Rev Nanomed Nanobiotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  530-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 John Wiley & Sons, Inc.
Departmentof Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
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MeSH Terms
Adenosine Triphosphate / administration & dosage*,  chemistry
Drug Delivery Systems / methods*
Liposomes / administration & dosage*,  chemistry
Myocardial Ischemia / drug therapy*
Reg. No./Substance:
0/Liposomes; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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