Document Detail

ATP-MgCl2 treatment after experimental acute myocardial ischemia and reperfusion.
MedLine Citation:
PMID:  11019598     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The effect of ATP-MgCl2 on myocardial metabolism and hemodynamics was investigated in this study. METHODS: Twelve dogs were entered in this research. Six dogs received ATP-MgCl2 and the remaining dogs were considered as controls. The amount of ATP and MgCl2 concentration of this solution is 100 mumol/ml each. The volume administered to the animals during the aortic occlusion is 0.25 ml/kg/hour; in the solution are 100 mumol/ml dose each. The volume administered to the animals during reperfusion is 0.25 ml/kg/hour. The left anterior descending artery was occluded for a period of one hour and the drug was administered during reperfusion. RESULTS: Three hours after reperfusion, cardiac output was 1524 +/- 26 ml/min in the control group and 1638 +/- 47 ml/min in the ATP-MgCl2 group (p < 0.05), pulmonary capillary wedge pressure was 14 +/- 3 in the control group and 8 +/- 2 in the ATP-MgCl2 group. At the same time interval tissue ATP and lactate level was 7 +/- 3, 1.3 +/- 0.4 in the control group and 14 +/- 2, 0.0 +/- 0.2 in the ATP-MgCl2 group respectively (p < 0.05). CONCLUSIONS: In this study we demonstrated that ATP-MgCl2 usage after one hour of arterial occlusion protects the heart from the adverse effects of ischemia/reperfusion.
S F Katircioğlu; A T Ulus; Z Saritaş
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Panminerva medica     Volume:  42     ISSN:  0031-0808     ISO Abbreviation:  Panminerva Med     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-10-18     Completed Date:  2000-10-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0421110     Medline TA:  Panminerva Med     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  11-5     Citation Subset:  IM    
Cardiovascular Surgery Department, Türkiye Yüksek Ihtisas Hospital of Ankara, Turkey.
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MeSH Terms
Adenosine Triphosphate / therapeutic use*
Coronary Circulation / drug effects
Heart / drug effects
Hemodynamics / drug effects
Myocardial Ischemia / drug therapy*
Myocardial Reperfusion Injury / drug therapy*
Myocardium / metabolism
Reg. No./Substance:
56-65-5/Adenosine Triphosphate

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