| AT(1) receptors and control of blood pressure: the kidney and more... | |
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MedLine Citation:
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PMID: 17210476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The renin-angiotensin system (RAS) is a critical regulator of blood pressure and fluid homeostasis. The components of the RAS including renin, angiotensin-converting enzyme, and angiotensin receptors are expressed throughout the body in tissues that may impact blood pressure control. Blocking actions of individual components of the RAS including renin, angiotensin-converting enzyme, or the type 1 (AT(1)) receptor lowers blood pressure. Although it has been suggested that control of sodium excretion by the kidney is the dominant mechanism for blood pressure regulation by the RAS, pharmacologic antagonists or conventional gene-targeting experiments globally interrupt the RAS and cannot discriminate its actions in the kidney from other tissue compartments. Recent experiments with the use of kidney cross-transplantation and genetically engineered mice suggest independent and equivalent effects of angiotensin II acting via AT(1) receptors in the kidney and in extrarenal tissues to maintain the normal level of blood pressure. However, the nature and relative contributions of these actions may differ in hypertension. |
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Authors:
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Steven D Crowley; Susan B Gurley; Thomas M Coffman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Trends in cardiovascular medicine Volume: 17 ISSN: 1050-1738 ISO Abbreviation: Trends Cardiovasc. Med. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-09 Completed Date: 2007-03-19 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 9108337 Medline TA: Trends Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 30-4 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology* Humans Hypertension, Renal / physiopathology* Kidney / physiology* Receptor, Angiotensin, Type 1 / physiology* Renin-Angiotensin System / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL56122/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptor, Angiotensin, Type 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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