Document Detail

AT(1) receptors and control of blood pressure: the kidney and more...
MedLine Citation:
PMID:  17210476     Owner:  NLM     Status:  MEDLINE    
The renin-angiotensin system (RAS) is a critical regulator of blood pressure and fluid homeostasis. The components of the RAS including renin, angiotensin-converting enzyme, and angiotensin receptors are expressed throughout the body in tissues that may impact blood pressure control. Blocking actions of individual components of the RAS including renin, angiotensin-converting enzyme, or the type 1 (AT(1)) receptor lowers blood pressure. Although it has been suggested that control of sodium excretion by the kidney is the dominant mechanism for blood pressure regulation by the RAS, pharmacologic antagonists or conventional gene-targeting experiments globally interrupt the RAS and cannot discriminate its actions in the kidney from other tissue compartments. Recent experiments with the use of kidney cross-transplantation and genetically engineered mice suggest independent and equivalent effects of angiotensin II acting via AT(1) receptors in the kidney and in extrarenal tissues to maintain the normal level of blood pressure. However, the nature and relative contributions of these actions may differ in hypertension.
Steven D Crowley; Susan B Gurley; Thomas M Coffman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  17     ISSN:  1050-1738     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-09     Completed Date:  2007-03-19     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  30-4     Citation Subset:  IM    
Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA.
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MeSH Terms
Blood Pressure / physiology*
Hypertension, Renal / physiopathology*
Kidney / physiology*
Receptor, Angiotensin, Type 1 / physiology*
Renin-Angiotensin System / physiology*
Grant Support
Reg. No./Substance:
0/Receptor, Angiotensin, Type 1

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