Document Detail


ASCUS, mature metaplastic type. Cytologic diagnosis and follow-up.
MedLine Citation:
PMID:  11284305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study the cytologic criteria for follow-up of mature metaplastic cells within the atypical squamous cells of undetermined significance (ASCUS) category. STUDY DESIGN: Squamous epithelial abnormalities between January 1994 and June 1997 at our institution totaled 2,632 and included squamous carcinoma (1), high grade squamous intraepithelial lesions (278), low grade squamous intraepithelial lesions (875) and ASCUS (1,478). From the ASCUS group, 134 (9.06%) were metaplastic; 89 were selected for review. Criteria for case selection were follow-up with tissue biopsy or at least two Pap smears and no previous epithelial abnormality. Patients ranged from 27 to 70 years of age. Parameters tabulated included number of abnormal cells per slide, their architecture, cell size, shape, cytoplasmic hue and texture, nuclear size and contour, chromatin pattern and nucleoli. Additionally, specimens were reviewed for hormonal status and inflammation. The findings were correlated with follow-up data. RESULTS: Cells generally appeared single or in loose, monolayered sheets of three to seven cells per group. The cells were well demarcated, polygonal or oval and ranged from 11 to 30 microns with cyanophilic or eosinophilic thickened cytoplasm. The round to oval nuclei with slight irregularity showed a minimally increased nuclear/cytoplasmic ratio with stippled chromatin. Upon review, 69 smears were confirmed as ASCUS-M. Follow-up revealed 42 with benign findings, 9 with persistent ASCUS/ASCUS-M and 18 with low grade squamous intraepithelial lesions. CONCLUSION: In mature metaplastic cells with minimal atypia in patients with no previous or concurrent dysplasia, the follow-up details were similar to those described for ASCUS-superficial/immediate squamous cells. These patients could be followed conservatively.
Authors:
D Gupta; V Kannan; G Komaromy-Hiller; T S Kline
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  45     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    2001 Mar-Apr
Date Detail:
Created Date:  2001-04-03     Completed Date:  2001-04-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  192-6     Citation Subset:  IM    
Affiliation:
Department of Pathology, Magee Women's Hospital and University of Pittsburgh, Pittsburgh, Pennsylvania, USA. dgupta@mail.magee.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cell Nucleus / ultrastructure
Cell Size
Female
Follow-Up Studies
Humans
Metaplasia / pathology*
Middle Aged
Neoplasms, Squamous Cell / pathology*,  ultrastructure
Retrospective Studies
Uterine Cervical Neoplasms / pathology*,  ultrastructure
Vaginal Smears

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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