| ARF in the mitochondria: the last frontier? | |
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MedLine Citation:
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PMID: 19033735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The tumor suppressor ARF carries out different functions in different cellular compartments. In the nucleus, ARF interacts physically and functionally with Mdm2 to inhibit cell cycle progression through activation of p53. In the nucleolus, ARF interacts with B23/NPM to inhibit ribosomal biogenesis through control of rRNA processing. Recent studies have expanded ARF's territory into the mitochondria. New data have shown that ARF interacts with the mitochondrial protein p32/C1QBP and that the interaction is critical in order for ARF to localize to the mitochondria and induce apoptosis. Remarkably, the ARF-p32 interaction, and hence ARF's pro-apoptotic function, can be interrupted by human cancer-derived mutations in exon2 of the p14(ARF)-p16(INK4a) gene locus. Here, we discuss the implications of these studies and their potential relevance to human cancer. |
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Authors:
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Koji Itahana; Hilary V Clegg; Yanping Zhang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-12-16 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 7 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-23 Completed Date: 2009-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 3641-6 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cytoplasm
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metabolism Humans Mitochondria / metabolism* Mitochondrial Proteins / metabolism Models, Biological Protein Transport Tumor Suppressor Protein p14ARF / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Mitochondrial Proteins; 0/Tumor Suppressor Protein p14ARF; 0/mitochondrial p32 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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