Document Detail

ARDS in patients with thermal injury.
MedLine Citation:
PMID:  10654206     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the time to onset of the adult respiratory distress syndrome (ARDS) in patients with thermal injury requiring mechanical ventilation. Secondarily, to consider the burn-related risk factors, demographics, incidence, and mortality for ARDS in this population. DESIGN: Retrospective chart review; ARDS defined according to the American-European Consensus Conference and the Lung Injury Severity Score definitions. SETTING: Regional, tertiary referral, adult burn unit in a university teaching hospital. PATIENTS AND PARTICIPANTS: Patients with thermal injury requiring mechanical ventilation, admitted between 1 January 1991 and 28 February 1995. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: Of 469 consecutive admissions, 126 (26.9%) received intubation and mechanical ventilation. ARDS was defined according to the American-European Consensus and Lung Injury Severity Score (score > 2.5) definitions. The mean time to onset of ARDS from admission to the burn unit was 6.9 +/- 5.2 and 8.2 +/- 10.7 days when defined by the American-European Consensus and Lung Injury Severity Score definitions respectively (p = 0.41). Of the intubated patients, 53.6 and 45.2% developed ARDS according to the American-European Consensus and Lung Injury Severity Score definitions, respectively (p = 0.19). Using multivariate logistic analysis, only age proved to be an independent risk factor for the development of ARDS (p = 0.03), although there was a trend toward an increased incidence of inhalation injury in patients with ARDS. Mortality was not significantly greater (41.8 vs 32.2%) in those with ARDS compared to those without (p = 0.27). CONCLUSIONS: According to the American-European Consensus Conference and the Lung Injury Severity Score definitions, ARDS is common in the adult burn population and has a delayed onset compared to most critical care populations. We found age to be a major predisposing factor for ARDS.
D R Dancey; J Hayes; M Gomez; D Schouten; J Fish; W Peters; A S Slutsky; T E Stewart
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Intensive care medicine     Volume:  25     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-02-24     Completed Date:  2000-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1231-6     Citation Subset:  IM    
Division of Respiratory Medicine, Mt. Sinai Hospital, University of Toronto, Ontario, Canada.
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MeSH Terms
Age Factors
Burns, Inhalation / complications*
Disease Progression
Medical Records
Middle Aged
Ontario / epidemiology
Respiration, Artificial*
Respiratory Distress Syndrome, Adult / etiology*,  mortality*,  therapy
Retrospective Studies
Risk Factors
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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