Document Detail

APOE modifies the association between Aβ load and cognition in cognitively normal older adults.
MedLine Citation:
PMID:  22189452     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the relationship between β-amyloid (Aβ) load as measured by [(11)C]-Pittsburgh compound B (PiB) PET and cognitive function in cognitively normal older adults.
METHODS: We studied 408 cognitively normal older adults who participated in the population-based Mayo Clinic Study of Aging (MCSA) from January 2009 through March 2011. The participants underwent PiB PET and neuropsychometric testing within 6 months. The association between PiB retention and cognitive function was measured by partial correlation and an interaction with APOE status was tested using linear regression after adjusting for age, sex, and education.
RESULTS: Higher PiB retention was associated with cognitive performance (Spearman partial r = -0.18; p < 0.01), specifically the memory, language, attention/executive, and visual-spatial processing domains in the whole group of participants. The association between PiB retention and cognition was modified by the APOE status on linear regression analysis even after controlling for the differences in the distribution of PiB values among APOE ε4 carriers and noncarriers (p = 0.02). Cognitive performance was associated with the Aβ deposition in the frontal, temporal, and parietal lobe association cortices in APOE ε4 carriers on SPM analysis (p < 0.001).
CONCLUSION: There is a modest association between PiB retention and cognitive function in cognitively normal older adults and this relationship between Aβ load and cognitive function is modified by APOE status. Whereas Aβ load is associated with greater cognitive impairment in APOE ε4 carriers, the cognitive function in APOE ε4 noncarriers is influenced less by the Aβ load, suggesting that APOE isoforms modulate the harmful effects of Aβ on cognitive function.
K Kantarci; V Lowe; S A Przybelski; S D Weigand; M L Senjem; R J Ivnik; G M Preboske; R Roberts; Y E Geda; B F Boeve; D S Knopman; R C Petersen; C R Jack
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-12-21
Journal Detail:
Title:  Neurology     Volume:  78     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-24     Completed Date:  2012-03-06     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  232-40     Citation Subset:  AIM; IM    
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
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MeSH Terms
Aged, 80 and over
Amyloid beta-Peptides / metabolism*
Apolipoproteins E / genetics*,  physiology*
Cognition / physiology*
Cohort Studies
Executive Function / physiology
Magnetic Resonance Imaging
Memory / physiology
Neuropsychological Tests
Positron-Emission Tomography
Psychomotor Performance / physiology
Grant Support
C06 RR018898/RR/NCRR NIH HHS; K23 AG030935/AG/NIA NIH HHS; K23 AG030935/AG/NIA NIH HHS; R01 AG011378/AG/NIA NIH HHS; R01 AG040042/AG/NIA NIH HHS; R01 AG11378/AG/NIA NIH HHS; U01 AG 06786/AG/NIA NIH HHS
Reg. No./Substance:
0/Amyloid beta-Peptides; 0/Apolipoproteins E
Comment In:
Neurology. 2012 Jan 24;78(4):228-9   [PMID:  22189449 ]

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