Document Detail

APOE genotype influences triglyceride and C-reactive protein responses to altered dietary fat intake in UK adults.
MedLine Citation:
PMID:  23134888     Owner:  NLM     Status:  Publisher    
BACKGROUND: The response of plasma lipids to dietary fat manipulation is highly heterogeneous, with some indications that APOE genotype may be important. OBJECTIVE: The objective was to use a prospective recruitment approach to determine the effect of dietary fat quantity and composition on both lipid and nonlipid cardiovascular disease biomarkers according to APOE genotype. DESIGN: Participants had a mean (±SD) age of 51 ± 9 y and a BMI (in kg/m(2)) of 26.0 ± 3.8 (n = 44 E3/E3, n = 44 E3/E4) and followed a sequential dietary intervention (the SATgenε study) in which they were assigned to a low-fat diet, a high-fat high-SFA (HSF) diet, and the HSF diet with 3.45 g DHA/d (HSF-DHA), each for 8 wk. Fasting blood samples were collected at the end of each intervention arm. RESULTS: An overall diet effect was evident for all cholesterol fractions (P < 0.01), with no significant genotype × diet interactions observed. A genotype × diet interaction (P = 0.033) was evident for plasma triglycerides, with 17% and 30% decreases in APOE3/E3 and APOE3/E4 individuals after the HSF-DHA diet relative to the low-fat diet. A significant genotype × diet interaction (P = 0.009) was also observed for C-reactive protein (CRP), with only significant increases in concentrations after the HSF and HSF-DHA diets relative to the low-fat diet in the APOE3/E4 group (P < 0.015). CONCLUSIONS: Relative to the wild-type APOE3/E3 group, our results indicate a greater sensitivity of fasting triglycerides and CRP to dietary fat manipulation in those with an APOE3/E4 genotype (25% population), with no effect of this allelic profile on cholesterol concentrations. The SATgenε study was registered at as NCT01384032.
Andrew L Carvalho-Wells; Kim G Jackson; Stacey Lockyer; Julie A Lovegrove; Anne M Minihane
Related Documents :
23900008 - The inhibitory effect of black soybean on hepatic cholesterol accumulation in high chol...
23747628 - Effects of tomato pomace supplementation on carcass characteristics and meat quality of...
23026518 - Dietary calcium decreases plasma cholesterol level only in female but not in male hamst...
23278338 - Biodiversity and composition of methanogenic populations in the rumen of cows fed alfal...
20025918 - Cholesterol depletion attenuates tonic release but increases the ambient level of gluta...
21393268 - Historical and contemporary perspectives on children's diets: is choice always in the p...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-7
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  -     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, Department of Food and Nutritional Sciences, University of Reading, Reading, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Multiple micronutrient supplementation in Tanzanian infants born to HIV-infected mothers: a randomiz...
Next Document:  Calcium intake is not associated with increased coronary artery calcification: the Framingham Study.