Document Detail


APOE genotype, ethnicity, and the risk of cerebral hemorrhage.
MedLine Citation:
PMID:  18256366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The apolipoprotein E (APOE) polymorphism is an established risk factor for intracerebral hemorrhage (ICH) that is related to cerebral amyloid angiopathy in the white population. Among Asian populations, although ICH represents up to one third of all strokes and has high rates of mortality and morbidity, the role of the APOE polymorphism has not been well studied. METHODS: The Perindopril Protection Against Recurrent Stroke Study (PROGRESS) was a randomized, double-blind, placebo-controlled trial of a blood pressure lowering regimen in subjects with prior cerebrovascular disease. APOE status was determined for 5,671 patients, including 2,148 Asians (38%). RESULTS: During the 3.9 years of follow-up, ICH occurred in 99 patients. Overall, carrying an epsilon 2 or epsilon 4 allele of the APOE polymorphism was associated with an adjusted hazard ratio (HR(a)) of 1.85 (95% CI = 1.24 to 2.76). In Asian patients the risk of ICH for epsilon 2 or epsilon 4 carriers was 2.11 (95% CI = 1.28 to 3.47) and 1.48 (95% CI = 0.76 to 2.87) in Europeans. Carriers of the epsilon 2 or epsilon 4 allele had an increased risk of both incident and recurrent ICH, and both cortical and deep ICH, and most risk estimates were higher in Asians than in Europeans. For both ethnic groups and for subtypes of ICH active treatment more than halved the risk of ICH and the treatment effects were not different in carriers of the epsilon 2 or epsilon 4 allele and in those with the epsilon 3 epsilon 3 genotype. CONCLUSIONS: There is a strong association between APOE genotype and the risk of intracerebral hemorrhage (ICH). In Asian patients the role of APOE polymorphisms in ICH is much broader than was previously supposed.
Authors:
C Tzourio; H Arima; S Harrap; C Anderson; O Godin; M Woodward; B Neal; M-G Bousser; J Chalmers; F Cambien; S MacMahon
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-02-06
Journal Detail:
Title:  Neurology     Volume:  70     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-16     Completed Date:  2008-05-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1322-8     Citation Subset:  AIM; IM    
Affiliation:
INSERM U708, 75651 Paris cedex 13, France. tzourio@chups.jussieu.fr
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MeSH Terms
Descriptor/Qualifier:
Aged
Apolipoprotein E2 / genetics
Apolipoprotein E4 / genetics
Apolipoproteins E / genetics*
Asian Continental Ancestry Group / ethnology,  genetics
Cerebral Hemorrhage / epidemiology,  ethnology*,  genetics*
Double-Blind Method
Europe / epidemiology,  ethnology
Female
Follow-Up Studies
Genetic Predisposition to Disease / epidemiology,  ethnology,  genetics
Genotype
Humans
Incidence
Internationality
Male
Middle Aged
Polymorphism, Genetic / genetics
Recurrence
Risk Factors
Stroke / epidemiology,  ethnology,  genetics
Chemical
Reg. No./Substance:
0/Apolipoprotein E2; 0/Apolipoprotein E4; 0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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