Document Detail


APOE and AD concordance in twin pairs as predictors of AD in first-degree relatives.
MedLine Citation:
PMID:  10680788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the independent effects of the APOE genotype (APOE) and concordance for AD in twin pairs on the occurrence of AD in first-degree relatives. BACKGROUND: Studies of twins have been undertaken to investigate the influence of genes in a variety of conditions, including AD. A previous study, performed before reports linking APOE to AD, demonstrated an increase in AD among first-degree relatives of twins concordant for AD compared with relatives of discordant twins. METHODS: In a sample of 94 twin pairs the authors examined the association between concordance for AD within the twin pair and family history of AD among first-degree relatives of twins. They then examined the extent to which the presence of the APOE epsilon4 allele in the twin pair explains the association between concordance for AD within the twin pair and family history of AD. RESULTS: Concordance among twins was associated with increased risk of AD among relatives (logrank test, chi2 = 12.558; p = 0.0004), and the presence of at least one APOE epsilon4 allele in each member of the twin pair is also associated with increased risk of AD among family members (logrank test, chi2 = 7.712; p = 0.0055). CONCLUSIONS: APOE genotype explains much but not all of the association between concordance among twins and increased familial risk of AD.
Authors:
D C Steffens; B L Plassman; M J Helms; K A Welsh-Bohmer; T T Newman; J C Breitner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  54     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-28     Completed Date:  2000-03-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  593-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Descriptor/Qualifier:
Age of Onset
Aged
Aged, 80 and over
Alleles
Alzheimer Disease / genetics*
Apolipoproteins E / genetics*
Diseases in Twins*
Genotype
Humans
Middle Aged
Predictive Value of Tests
Grant Support
ID/Acronym/Agency:
AG08549/AG/NIA NIH HHS; K07 MH01367/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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