| APOBEC3B deletion and risk of HIV-1 acquisition. | |
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MedLine Citation:
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PMID: 19698078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The human APOBEC3 family of cytidine deaminases provides intrinsic immunity to retroviral infection. A naturally occurring 29.5-kb deletion removes the entire APOBEC3B gene. We examined the impact of the APOBEC3B gene deletion in >4000 individuals from 5 human immunodeficiency virus type 1 (HIV-1) natural history cohorts. The hemizygous genotype had no effect on either acquisition of HIV-1 infection or progression to AIDS. However, the homozygous deletion was significantly associated with unfavorable outcomes for HIV-1 acquisition (odds ratio, 7.37; P= .024), progression to AIDS (relative hazard, 4.01; P=. 03), and viral set point (P= .04). These findings suggest that the loss of APOBEC3B may increase host susceptibility to HIV-1 acquisition and progression to AIDS and warrant further study. |
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Authors:
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Ping An; Randall Johnson; John Phair; Gregory D Kirk; Xiao-Fang Yu; Sharyne Donfield; Susan Buchbinder; James J Goedert; Cheryl A Winkler |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 200 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-02 Completed Date: 2009-10-28 Revised Date: 2012-04-24 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1054-8 Citation Subset: AIM; IM |
Affiliation:
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Laboratory of Genomic Diversity, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, MD 21702, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cytidine Deaminase
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genetics* Ethnic Groups Gene Deletion Gene Expression Regulation / physiology Genetic Predisposition to Disease* HIV Infections / genetics* HIV-1* Heterozygote Homozygote Humans |
| Grant Support | |
ID/Acronym/Agency:
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R01 DA004334/DA/NIDA NIH HHS; R01-12586//PHS HHS; R01-DA04334/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.5.4.5/APOBEC3B protein, human; EC 3.5.4.5/Cytidine Deaminase |
| Comments/Corrections | |
Comment In:
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J Infect Dis. 2010 Sep 1;202(5):815-6; author reply 816-7
[PMID:
20684727
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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