| APOA5-1131T>C genotype effects on apolipoprotein A5 and triglyceride levels in response to dietary intervention and regular exercise (DIRE) in hypertriglyceridemic subjects. | |
| | |
MedLine Citation:
|
PMID: 20392444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: We aimed to determine the influence of apolipoprotein A5 gene (APOA5)-1131T>C single nucleotide polymorphism on the effects of dietary intervention and regular exercise (DIRE) targeting ApoA5 and triglyceride (TG) concentrations. METHODS: Hypertriglyceridemia patients (TG, 150-500mg/dL, n=283) undertook a 12-week DIRE (replacing 1/3 of refined rice in their diets with legumes, increasing vegetable intake, and regular walking). RESULTS: Pre-treatment, no genotype-related differences were detected in ApoA5, TG, or HDL cholesterol levels; however, post-treatment, subjects homozygous (T/T) for the T allele had lower serum TG (P=0.009) and higher HDL cholesterol (P=0.036) than other subjects. In T/T subjects, after adjustments for age, sex and weight changes (r1) or initial TG levels (r2), changes in ApoA5 levels negatively correlated with TG changes (r1=-0.29, P=0.05, r2=-0.28, P<0.1) and positively correlated with changes in HDL cholesterol (r1=0.30, P<0.05, r2=0.32, P<0.05) and free fatty acid (r1=0.38, P<0.01, r2=0.40, P<0.01). In those with moderate hypertriglyceridemia (TG, 200-500mg/dL, n=130), APOA5-1131T/T carriers achieved significantly lower TG (P=0.007) and higher HDL cholesterol (P<0.001) than -1131C allele carriers. Additionally, statistically significant interactions between the -1131T>C and the compliance of DIRE were found for the change in TG (P=0.002) and HDL cholesterol (P=0.039). In good compliance group, T/T subjects showed greater reduction of TG and higher increase of HDL cholesterol than other subjects. On the other hand, non-good compliance group had no significant improvement in these variables. CONCLUSIONS: APOA5-1131T/T carriers may benefit more from the DIRE than C allele carriers. These effects were remarkable in patients with moderate hypertriglyceridemia and the individuals with good compliance. |
| | |
Authors:
|
Yangsoo Jang; Jey Sook Chae; Oh Yoen Kim; Hey Jun Park; Ji Young Kim; Jean Kyung Paik; Sang-Hyun Lee; Jong Ho Lee |
Related Documents
:
|
11181754 - Apoa-ii expression in cetp transgenic mice increases vldl production and impairs vldl c... 2233284 - Influence of cold exposure on plasma triglyceride clearance in humans. 22227174 - Prevention of salt-induced renal injury by activation of nad(p)h:quinone oxidoreductase... 17110604 - Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administe... 17311894 - Sex differences in abdominal, gluteal, and thigh lpl activity. 18566694 - Differences in trabecular bone of leptin-deficient ob/ob mice in response to biomechani... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-16 |
Journal Detail:
|
Title: Atherosclerosis Volume: 211 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-02 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
|
Languages: eng Pagination: 512-9 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anthropometry Apolipoproteins A / blood*, genetics* Cholesterol / metabolism Cholesterol, HDL / metabolism Diet* Exercise* Female Genotype* Humans Hypertriglyceridemia / diet therapy*, genetics* Korea Male Middle Aged Triglycerides / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/APOA5 protein, human; 0/Apolipoproteins A; 0/Cholesterol, HDL; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Who actually read Exner? Returning to the source of the frontal "writing centre" hypothesis.
Next Document: Time and depth dependent poisson's ratio of cartilage explained by an inhomogeneous orthotropic fibe...