| API2-MALT1 fusion gene in colorectal lymphoma. | |
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MedLine Citation:
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PMID: 14681324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The API2-MALT1 fusion gene was originally identified from a t(11;18)(q21;q21) translocation, a specific chromosomal abnormality that is found in mucosa-associated lymphoid tissue (MALT) lymphoma. Gastric MALT lymphomas positive for the API2-MALT1 fusion gene do not respond to Helicobacter pylori-eradication therapy, but otherwise, the incidence and clinicopathological behavior of colorectal MALT lymphoma with this genetic abnormality are unclear. We examined the API2-MALT1 fusion by multiplex RT-PCR method in 47 cases of MALT lymphoma and 13 cases of diffuse large B-cell lymphoma and evaluated the relevance of API2-MALT1 positivity to the clinical and pathological features. The mean ages of MALT lymphoma and diffuse large B-cell lymphoma patients were 65 (range, 37-87 y) and 58 (range, 14-85 y) years, respectively. API2-MALT1 fusion genes were detected in seven cases (15%) of MALT lymphoma and one case (8%) of diffuse large B-cell lymphoma. In MALT lymphomas, the tumor size in API2-MALT1-positive cases was 62 +/- 39 mm (mean +/- SD), statistically larger than that in API2-MALT1-negative cases (25 +/- 19 mm; P <.01). The API2-MALT1-positive cases demonstrated more advanced clinical stages and a male predominance, compared with API2-MALT1-negative cases. Thus, API2-MALT1-positive tumors should be cared for as a more aggressive subgroup and be followed for a longer time. |
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Authors:
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Sumie Takase Sakugawa; Tadashi Yoshino; Shigeo Nakamura; Hiroshi Inagaki; Yoshito Sadahira; Hirokazu Nakamine; Mitsukuni Okabe; Koichi Ichimura; Mitsune Tanimoto; Tadaatsu Akagi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Volume: 16 ISSN: 0893-3952 ISO Abbreviation: Mod. Pathol. Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-18 Completed Date: 2004-07-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8806605 Medline TA: Mod Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 1232-41 Citation Subset: IM |
Affiliation:
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Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing* Adult Aged Aged, 80 and over Colorectal Neoplasms / genetics, metabolism, pathology* Female Humans Immunohistochemistry Lymphoma, B-Cell / genetics, metabolism, pathology Lymphoma, B-Cell, Marginal Zone / genetics, metabolism, pathology* Lymphoma, Large B-Cell, Diffuse / genetics, metabolism, pathology Male Middle Aged Neoplasm Proteins / analysis Neoplasm Staging Oncogene Proteins, Fusion / genetics* RNA, Neoplasm / genetics, metabolism Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/API2-MALT1 fusion protein, human; 0/Adaptor Proteins, Signal Transducing; 0/BCL10 protein, human; 0/Neoplasm Proteins; 0/Oncogene Proteins, Fusion; 0/RNA, Neoplasm |
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