Document Detail

API2-MALT1 fusion gene in colorectal lymphoma.
MedLine Citation:
PMID:  14681324     Owner:  NLM     Status:  MEDLINE    
The API2-MALT1 fusion gene was originally identified from a t(11;18)(q21;q21) translocation, a specific chromosomal abnormality that is found in mucosa-associated lymphoid tissue (MALT) lymphoma. Gastric MALT lymphomas positive for the API2-MALT1 fusion gene do not respond to Helicobacter pylori-eradication therapy, but otherwise, the incidence and clinicopathological behavior of colorectal MALT lymphoma with this genetic abnormality are unclear. We examined the API2-MALT1 fusion by multiplex RT-PCR method in 47 cases of MALT lymphoma and 13 cases of diffuse large B-cell lymphoma and evaluated the relevance of API2-MALT1 positivity to the clinical and pathological features. The mean ages of MALT lymphoma and diffuse large B-cell lymphoma patients were 65 (range, 37-87 y) and 58 (range, 14-85 y) years, respectively. API2-MALT1 fusion genes were detected in seven cases (15%) of MALT lymphoma and one case (8%) of diffuse large B-cell lymphoma. In MALT lymphomas, the tumor size in API2-MALT1-positive cases was 62 +/- 39 mm (mean +/- SD), statistically larger than that in API2-MALT1-negative cases (25 +/- 19 mm; P <.01). The API2-MALT1-positive cases demonstrated more advanced clinical stages and a male predominance, compared with API2-MALT1-negative cases. Thus, API2-MALT1-positive tumors should be cared for as a more aggressive subgroup and be followed for a longer time.
Sumie Takase Sakugawa; Tadashi Yoshino; Shigeo Nakamura; Hiroshi Inagaki; Yoshito Sadahira; Hirokazu Nakamine; Mitsukuni Okabe; Koichi Ichimura; Mitsune Tanimoto; Tadaatsu Akagi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  16     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-18     Completed Date:  2004-07-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1232-41     Citation Subset:  IM    
Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
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MeSH Terms
Adaptor Proteins, Signal Transducing*
Aged, 80 and over
Colorectal Neoplasms / genetics,  metabolism,  pathology*
Lymphoma, B-Cell / genetics,  metabolism,  pathology
Lymphoma, B-Cell, Marginal Zone / genetics,  metabolism,  pathology*
Lymphoma, Large B-Cell, Diffuse / genetics,  metabolism,  pathology
Middle Aged
Neoplasm Proteins / analysis
Neoplasm Staging
Oncogene Proteins, Fusion / genetics*
RNA, Neoplasm / genetics,  metabolism
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/API2-MALT1 fusion protein, human; 0/Adaptor Proteins, Signal Transducing; 0/BCL10 protein, human; 0/Neoplasm Proteins; 0/Oncogene Proteins, Fusion; 0/RNA, Neoplasm

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