Document Detail


APE1 and XRCC3 polymorphisms and myocardial infarction.
MedLine Citation:
PMID:  18712175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In most cells, DNA is regularly damaged by mutagens. Different DNA repair mechanisms operate on specific types of damaged DNA. When DNA damage resulting from free radicals is not repaired, it might lead to deteriorated gene expression, the development of a number of diseases such as cancer, diabetes, vascular diseases, and aging. In the present study, APE1 and XRCC3 gene polymorphisms were investigated in patients with myocardial infarction. MATERIALS AND METHODS: Forty-five first time elective coronary artery bypass grafting (CABG) patients with cardiopulmonary bypass (CPB) and 40 healthy individuals were studied. Gene polymorphisms were determined by a polymerase chain reaction-restriction fragment length polymorphism method. RESULTS: For the APE1 gene, the AG genotype was significantly higher in the patient group than in the control group. The patient group had significantly more G carriers but there was no statistically significant difference between patient and control groups the A allele. The XRCC3 TT genotype was found to be significantly more frequent in the patient group than it was in the control group. CONCLUSION: The results of our study suggested that the XRCC3 gene TT genotype and the APE1 gene AG genotype might increase the risk of myocardial infarcts.
Authors:
Atike Tekeli; Selim Isbir; Arzu Ergen; Uzay Görmüş; Nilüfer Bozkurt; Ozlem Timirci; Sinan Arsan; Turgay Isbir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  22     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2008 Jul-Aug
Date Detail:
Created Date:  2008-08-20     Completed Date:  2008-09-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  477-9     Citation Subset:  IM    
Affiliation:
Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University, Capa-Istanbul, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Case-Control Studies
Coronary Artery Bypass
DNA Primers / chemistry
DNA Repair
DNA-(Apurinic or Apyrimidinic Site) Lyase / genetics*,  physiology*
DNA-Binding Proteins / genetics*,  physiology*
Genotype
Heterozygote
Homozygote
Humans
Myocardial Infarction / genetics*,  pathology*
Phenotype
Polymorphism, Genetic*
Risk
Chemical
Reg. No./Substance:
0/DNA Primers; 0/DNA-Binding Proteins; 0/X-ray repair cross complementing protein 3; EC 4.2.99.18/APEX1 protein, human; EC 4.2.99.18/DNA-(Apurinic or Apyrimidinic Site) Lyase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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