Document Detail

AP-1 transcription factor complexes in CNS disorders and development.
MedLine Citation:
PMID:  7561734     Owner:  NLM     Status:  MEDLINE    
Transcription factors are regulatory proteins that modify gene expression. Any cellular function requiring alterations in mRNA levels depends upon these factors. The CNS, AP-1 (activator protein-1; c-fos and fos-related antigens plus jun-related factors) and CREB (cAMP responsive element binding protein) families of transcription factors have been extensively studied. The DNA binding complex is composed of dimers formed between the AP-1 and CREB factors and binding specificity is dictated by which proteins comprise the complex. Whereas the AP-1 factors are inducible, CREB and related proteins are constitutive and regulate gene transcription through phosphorylation. Due to seizure activity, many AP-1 factors are induced, but rapidly return to basal levels. However, if neuronal death occurs, fos-related antigens of 35 kDa persist for an extended period and may be involved in regulating genes related to neuronal plasticity. Similar factors are expressed after chronic drug treatment indicating a role in drug tolerance. However, during early CNS development, elevated AP-1 DNA binding consisting of c-jun and CREB occurs in every brain region and is inversely related to the degree of maturation of a particular brain area. These transcription factors are important for gene regulation during CNS dysfunction and development and those present specify which genes are activated.
K R Pennypacker
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of the Florida Medical Association     Volume:  82     ISSN:  0015-4148     ISO Abbreviation:  J Fla Med Assoc     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-11-03     Completed Date:  1995-11-03     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7505604     Medline TA:  J Fla Med Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  551-4     Citation Subset:  IM    
Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa, USA.
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MeSH Terms
Activating Transcription Factor 2
Brain / metabolism
Cell Death
Central Nervous System Diseases / genetics*,  physiopathology
Cyclic AMP Response Element-Binding Protein / genetics,  physiology
Gene Expression Regulation
Leucine Zippers / genetics,  physiology*
Neuronal Plasticity / genetics
Neurons / physiology
Proto-Oncogene Proteins c-fos / genetics,  physiology
Proto-Oncogene Proteins c-jun / genetics,  physiology
Seizures / genetics,  metabolism
Transcription Factor AP-1 / genetics,  physiology*
Transcription Factors*
Reg. No./Substance:
0/Activating Transcription Factor 2; 0/Cyclic AMP Response Element-Binding Protein; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Transcription Factor AP-1; 0/Transcription Factors

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