Document Detail


AP-1 subunits: quarrel and harmony among siblings.
MedLine Citation:
PMID:  15564374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The AP-1 transcription factor is mainly composed of Jun, Fos and ATF protein dimers. It mediates gene regulation in response to a plethora of physiological and pathological stimuli, including cytokines, growth factors, stress signals, bacterial and viral infections, as well as oncogenic stimuli. Studies in genetically modified mice and cells have highlighted a crucial role for AP-1 in a variety of cellular events involved in normal development or neoplastic transformation causing cancer. However, emerging evidence indicates that the contribution of AP-1 to determination of cell fates critically depends on the relative abundance of AP-1 subunits, the composition of AP-1 dimers, the quality of stimulus, the cell type and the cellular environment. Therefore, AP-1-mediated regulation of processes such as proliferation, differentiation, apoptosis and transformation should be considered within the context of a complex dynamic network of signalling pathways and other nuclear factors that respond simultaneously.
Authors:
Jochen Hess; Peter Angel; Marina Schorpp-Kistner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of cell science     Volume:  117     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-26     Completed Date:  2005-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  5965-73     Citation Subset:  IM    
Affiliation:
Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, 69120 Heidelberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Apoptosis
Cell Differentiation
Cell Lineage
Cell Proliferation
Cell Survival
Dimerization
Hepatocytes / metabolism
Humans
Keratinocytes / metabolism
Models, Biological
Models, Molecular
Molecular Sequence Data
Neoplasms / metabolism
Protein Structure, Tertiary
Proto-Oncogene Proteins c-fos / metabolism
Proto-Oncogene Proteins c-jun / metabolism
Signal Transduction
Transcription Factor AP-1 / chemistry,  physiology*
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Transcription Factor AP-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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