Document Detail


AP-1 is required for the maintenance of apico-basal polarity in the C. elegans intestine.
MedLine Citation:
PMID:  22535414     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Epithelial tubes perform functions that are essential for the survival of multicellular organisms. Understanding how their polarised features are maintained is therefore crucial. By analysing the function of the clathrin adaptor AP-1 in the C. elegans intestine, we found that AP-1 is required for epithelial polarity maintenance. Depletion of AP-1 subunits does not affect epithelial polarity establishment or the formation of the intestinal lumen. However, the loss of AP-1 affects the polarised distribution of both apical and basolateral transmembrane proteins. Moreover, it triggers de novo formation of ectopic apical lumens between intestinal cells along the lateral membranes later during embryogenesis. We also found that AP-1 is specifically required for the apical localisation of the small GTPase CDC-42 and the polarity determinant PAR-6. Our results demonstrate that AP-1 controls an apical trafficking pathway required for the maintenance of epithelial polarity in vivo in a tubular epithelium.
Authors:
Massiullah Shafaq-Zadah; Lysiane Brocard; Florence Solari; Grégoire Michaux
Related Documents :
2880724 - T11ts, the cell surface molecule binding to the "erythrocyte receptor" of t lymphocytes...
1080784 - T-cell membrane characteristics of "mycosis cells" in the skin and lymph node.
22173634 - Perforin activity at membranes leads to invaginations and vesicle formation.
6831544 - Structure of the non-lymphoid cells during the postnatal development of the rat lymph n...
6411744 - Mapping of highly ordered membrane domains in the plasma membrane of the ciliate cyclid...
3336374 - Evidence for uptake of 8-methoxypsoralen and 5-methoxypsoralen by cellular nuclei.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-25
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  -     ISSN:  1477-9129     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  BMP and Delta/Notch signaling control the development of amphioxus epidermal sensory neurons: insigh...
Next Document:  Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune r...