Document Detail


Antenatal Bartter syndrome: analysis of two cases with placental findings.
MedLine Citation:
PMID:  20450264     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prenatal diagnosis of Bartter syndrome can be based on the high chloride level in the amniotic fluid. Microscopic examination of the placenta in untreated cases showed extensive mineralization in the chorionic villi in previous studies. Two cases were presented at 26-29 weeks of gestation with severe polyhydramnios. The mothers were treated with Indomethacin, KCl, and serial amniocentesis in order to reduce the amniotic fluid volume and prevent fetal hypokalemia. The microscopic examination of the placenta revealed focal calcification and acute atherosis in placental vessels. The treatment with Indomethacin in the antenatal period can prevent severe nephrocalcinosis.
Authors:
Banu Dane; Cem Dane; Figen Aksoy; Ahmet Cetin; Murat Yayla
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fetal and pediatric pathology     Volume:  29     ISSN:  1551-3823     ISO Abbreviation:  Fetal Pediatr Pathol     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230972     Medline TA:  Fetal Pediatr Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  121-6     Citation Subset:  IM    
Affiliation:
Department of Gynecology & Obstetrics, Haseki Training & Research Hospital, Istanbul, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amniocentesis
Amniotic Fluid / chemistry
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Arteriosclerosis / complications,  pathology
Bartter Syndrome / complications,  pathology*,  therapy
Chlorides / analysis
Chorionic Villi / blood supply,  pathology*
Female
Fetal Diseases / pathology*,  therapy
Gestational Age
Humans
Indomethacin / therapeutic use
Infant, Newborn
Male
Nephrocalcinosis / pathology,  prevention & control
Placenta Diseases / pathology*,  therapy
Polyhydramnios / etiology,  pathology*,  therapy
Potassium Chloride / therapeutic use
Pregnancy
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Chlorides; 53-86-1/Indomethacin; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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