Document Detail

ANG II receptors, c-myc, and c-jun in myocytes after myocardial infarction and ventricular failure.
MedLine Citation:
PMID:  8456979     Owner:  NLM     Status:  MEDLINE    
To determine the relationship between reactive cardiac hypertrophy and the expression of angiotensin II (ANG II) receptors in surviving myocytes after infarction, large infarcts were produced in rats that were killed 2-3 days later. Measurements of global ventricular dynamics indicated that left ventricular failure and right ventricular dysfunction occurred in experimental animals. These alterations in ventricular pump function were associated with increases in ventricular weight-to-body weight ratio, indicative of developing cardiac hypertrophy. Such a response was coupled with a 6.6-fold increase in ANG II receptor mRNA in myocytes from the left ventricle. A 2.3-fold increase in the expression of ANG II receptor in myocytes from the right ventricle was also found. Radioligand binding assay documented a 44% increase in the density of ANG II receptors on left ventricular myocytes of infarcted hearts. To establish whether the induction of genes commonly associated with myocyte hypertrophy was present, the message for c-myc and c-jun was biventricularly assessed. Myocardial infarction was accompanied by overexpressions of c-myc and c-jun that were more prominent in left than in right ventricular myocytes. In conclusion, the enhanced expression of ANG II receptor and its receptor protein and c-myc and c-jun in myocytes may participate in the reactive growth processes of these cells after infarction.
K Reiss; J M Capasso; H E Huang; L G Meggs; P Li; P Anversa
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  264     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-22     Completed Date:  1993-04-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H760-9     Citation Subset:  IM    
Department of Medicine, New York Medical College, Valhalla 10595.
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MeSH Terms
Base Sequence
Blood Pressure
Blotting, Northern
Cardiomegaly / genetics*
Gene Expression*
Genes, jun / genetics*
Genes, myc / genetics*
Heart Rate
Molecular Sequence Data
Myocardial Infarction / genetics*,  physiopathology
Myocardium / pathology
Nucleic Acid Hybridization
Organ Size
Polymerase Chain Reaction
RNA, Messenger / metabolism
Rats, Sprague-Dawley
Receptors, Angiotensin / genetics*
Grant Support
Reg. No./Substance:
0/RNA, Messenger; 0/Receptors, Angiotensin

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