Document Detail

ANCA against bactericidal/permeability-increasing protein, azurocidin, calprotectin and defensins in rheumatic and infectious diseases: prevalence and clinical associations.
MedLine Citation:
PMID:  14740437     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the prevalence and clinical associations of ANCA against the antibiotic proteins and peptides: Bactericidal/permeability-increasing protein (BPI), Azurocidin (AZ), Calprotectin (CP) and beta-Defensin-1 and -2 (DF). METHODS: Patients with ANCA-associated vasculitides (n = 99), other vasculitides and rheumatic connective tissue diseases (n = 303), HIV-infection (n = 66), other infectious diseases (n = 134) Crohn's disease (n = 12) and ulcerative colitis (n = 12) were tested for BPI-, AZ-, CP-, DF-, PR3-, and MPO-ANCA in indirect immunofluorescence technique (IFT) and ELISA. RESULTS: In ANCA associated vasculitides BPI-ANCA were detected in 6% of patients. In HIV infection, BPI was the main target antigen of ANCA-IFT positive sera (74%). BPI-ANCA was associated with higher inflammatory activity. In Crohn's disease and ulcerative colitis BPI-ANCA was prominent (34% of patients). AZ-ANCA were found in 5% of patients. No ANCA were detected against defensin and calprotectin. CONCLUSION: BPI-ANCA is the main autoantibody in HIV and is associated with higher inflammatory activity. In inflammatory bowel diseases BPI-ANCA is predominant, AZ-ANCA are also present to a lesser extend. Both were not useful characterize clinical subgroups. No ANCA were detected against calprotectin or defensins.
H Schultz; E Csernok; K Herlyn; P H Reichel; F Moosig; O A Cornely; M K Fagerhol; W L Gross
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  21     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2003 Nov-Dec
Date Detail:
Created Date:  2004-01-26     Completed Date:  2004-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S117-20     Citation Subset:  IM    
Department of Rheumatology, University of Lübeck, Lübeck, Germany.
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MeSH Terms
Antibodies, Antineutrophil Cytoplasmic / immunology*
Antimicrobial Cationic Peptides
Biological Markers
Blood Proteins / immunology*
Carrier Proteins / immunology
Defensins / immunology*
Diagnosis, Differential
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique, Indirect
Infection / diagnosis,  epidemiology,  immunology*
Leukocyte L1 Antigen Complex / immunology*
Membrane Proteins*
Middle Aged
Rheumatic Diseases / diagnosis,  epidemiology,  immunology*
Seroepidemiologic Studies
Reg. No./Substance:
0/Antibodies, Antineutrophil Cytoplasmic; 0/Antimicrobial Cationic Peptides; 0/Biological Markers; 0/Blood Proteins; 0/Carrier Proteins; 0/Defensins; 0/Leukocyte L1 Antigen Complex; 0/Membrane Proteins; 0/bactericidal permeability increasing protein; 0/cationic antimicrobial protein CAP 37, human

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