| AMY-1 is a trigger for the erythrocyte differentiation of K562 cells. | |
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MedLine Citation:
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PMID: 10639579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have reported that a novel c-Myc binding protein, AMY-1, stimulated the transcription activity of c-Myc and was translocated from cytoplasm to nuclei in a c-Myc-dependent manner. Here, the role of AMY-1 in cell differentiation was examined. AMY-1 expression was up-regulated after differentiation induction of human K562 cells to erythrocyte cells by AraC, while c-Myc expression was rapidly down-regulated. K562 cell lines expressing exogenous AMY-1 were established, and these cells expressed a high level of epsilon-globin mRNA, a marker gene necessary for erythrocyte cell differentiation, without differentiation induction. The addition of AraC rapidly initiated differentiation in these cell lines, which continued to differentiate to erythrocyte cells possessing a high level of hemoglobin even after the decrease in AMY-1 expression. These results suggest that AMY-1 is a trigger for K562 cells to differentiate to erythrocyte cells and that AMY-1 may have a function independent of or different from c-Myc. |
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Authors:
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M Furusawa; T Onishi; T Taira; S M Iguchi-Ariga; H Ariga |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of oncology Volume: 16 ISSN: 1019-6439 ISO Abbreviation: Int. J. Oncol. Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-03-07 Completed Date: 2000-03-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9306042 Medline TA: Int J Oncol Country: GREECE |
Other Details:
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Languages: eng Pagination: 339-45 Citation Subset: IM |
Affiliation:
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Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antimetabolites, Antineoplastic
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pharmacology Cell Differentiation / physiology* Cytarabine / pharmacology DNA-Binding Proteins / physiology* Globins / metabolism Humans K562 Cells / drug effects, metabolism* RNA, Messenger / metabolism* Transcription Factors / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites, Antineoplastic; 0/DNA-Binding Proteins; 0/MYCBP protein, human; 0/RNA, Messenger; 0/Transcription Factors; 147-94-4/Cytarabine; 9004-22-2/Globins |
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