Document Detail


AMSA--a promising new agent in refractory acute leukemia.
MedLine Citation:
PMID:  7046928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty-five patients with various forms of acute leukemia refractory to usual methods of treatment were treated with AMSA at doses of 100-200 mg/m2 iv daily for 5-7 days, for total doses of 500-1000 mg/m2/course. Among 41 evaluable patients, six (15%) achieved complete remissions, including two of 19 patients with typical acute nonlymphocytic leukemia, none of four with atypical acute nonlymphocytic leukemia, two of nine with chronic granulocytic leukemia in blast crisis, two of eight with acute lymphoblastic leukemia, and none of one with acute undifferentiated leukemia. Durations of complete remissions were 6, 7, 8, 12, 13, and 14 weeks. Four of the patients who died with infection during marrow hypoplasia 2-5 weeks after receiving AMSA had no evidence of leukemia on premortem bone marrow aspirates or postmortem examination. The primary toxic effects of AMSA were severe myelosuppression, stomatitis, and alopecia. One incident of life-threatening liver failure occurred. AMSA appears to be a promising agent for use in heavily pretreated patients with acute leukemia and chronic granulocytic leukemia in blast crisis.
Authors:
H J Lawrence; C A Ries; R D Reynolds; J P Lewis; M M Koretz; F M Torti
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer treatment reports     Volume:  66     ISSN:  0361-5960     ISO Abbreviation:  Cancer Treat Rep     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-09-10     Completed Date:  1982-09-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7607107     Medline TA:  Cancer Treat Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1475-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Aged
Aminoacridines / therapeutic use*
Amsacrine
Antineoplastic Agents / therapeutic use*
Child
Clinical Trials as Topic
Female
Follow-Up Studies
Humans
Leukemia / drug therapy*
Leukemia, Myeloid, Acute / drug therapy
Male
Middle Aged
Grant Support
ID/Acronym/Agency:
CA-21744/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Aminoacridines; 0/Antineoplastic Agents; 51264-14-3/Amsacrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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