| AMPA receptor trafficking in inflammation-induced dorsal horn central sensitization. | |
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MedLine Citation:
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PMID: 22466122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Activity-dependent postsynaptic receptor trafficking is critical for long-term synaptic plasticity in the brain, but it is unclear whether this mechanism actually mediates the spinal cord dorsal horn central sensitization (a specific form of synaptic plasticity) that is associated with persistent pain. Recent studies have shown that peripheral inflammation drives changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunit trafficking in the dorsal horn and that such changes contribute to the hypersensitivity that underlies persistent pain. Here, we review current evidence to illustrate how spinal cord AMPARs participate in the dorsal horn central sensitization associated with persistent pain. Understanding these mechanisms may allow the development of novel therapeutic strategies for treating persistent pain. |
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Authors:
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Yuan-Xiang Tao |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Neuroscience bulletin Volume: 28 ISSN: 1995-8218 ISO Abbreviation: Neurosci Bull Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-02 Completed Date: 2012-12-06 Revised Date: 2013-04-03 |
Medline Journal Info:
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Nlm Unique ID: 101256850 Medline TA: Neurosci Bull Country: China |
Other Details:
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Languages: eng Pagination: 111-20 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. ytao1@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chronic Pain / etiology, physiopathology* Glutamic Acid / physiology Humans Inflammation / complications, physiopathology* Neuronal Plasticity / physiology Nociceptors / physiology* Posterior Horn Cells / physiopathology* Protein Transport / physiology Receptors, AMPA / physiology* Synaptic Transmission / physiology |
| Grant Support | |
ID/Acronym/Agency:
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NS058886/NS/NINDS NIH HHS; NS072206/NS/NINDS NIH HHS; R01 NS058886-04/NS/NINDS NIH HHS; R01 NS072206-01A1/NS/NINDS NIH HHS; R01 NS072206-02/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, AMPA; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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