Document Detail

AMPA receptor antagonists reverse effects of extended habit training on signaled food approach responding in rats.
MedLine Citation:
PMID:  17634927     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Dopamine D1 receptor stimulation is critically involved in early appetitive phases of learning in various behavioral paradigms. However, extended habit training was previously shown to reduce the ability of dopamine D1 receptor antagonists such as R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH-23390) to disrupt behavioral performance. OBJECTIVE: The present study aimed to evaluate whether coadministration of glutamate alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor antagonists restores sensitivity to acute blockade of D1 receptors. MATERIALS AND METHODS: Adult male Wistar rats were presented with 45-mg food pellets delivered to the food tray, which was immediately preceded by a 400-ms tone (2.8 kHz, 78 dB). During each training and test session, there were 28 food-tone presentations with an average intertrial interval of 70 s, and each head entry into the food tray was recorded. Drug tests were conducted on either day 3 or 9 of the training using independent groups of animals. The main dependent variable was the number of trials during which no head-entry response was made during the 10-s period immediately after the food delivery. RESULTS: Longer training duration enhanced the resistance of the signaled food approach behavior to extinction and to disrupting effects of supplementary food ration. Similarly, acute administration of SCH-23390 (0.04-0.16 mg/kg) dose-dependently reduced the number of omitted trials when given before the test session on day 3 but much less so when injected on day 9. AMPA receptor antagonists, NBQX (10 mg/kg) or GYKI-52466 (3-10 mg/kg), had no effects on their own but significantly enhanced the disrupting effects of SCH-23390 (0.08 and 0.16 mg/kg) when given on day 9 but not on day 3 of the training. CONCLUSIONS: These results indicate that AMPA receptor blockade restores sensitivity to appetitive behavior-disrupting effects of SCH-23390 in subjects exposed to extended training protocol.
A Y Bespalov; S Harich; A-L Jongen-Rêlo; M M van Gaalen; G Gross
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Publication Detail:
Type:  Journal Article     Date:  2007-07-19
Journal Detail:
Title:  Psychopharmacology     Volume:  195     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-12     Completed Date:  2008-03-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  11-8     Citation Subset:  IM    
Neuroscience Research, GPRD, Abbott, 67008, Ludwigshafen, Germany.
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MeSH Terms
Appetitive Behavior / drug effects*,  physiology
Behavior, Animal / drug effects*,  physiology
Benzazepines / administration & dosage,  pharmacology
Benzodiazepines / administration & dosage,  pharmacology
Conditioning, Classical / drug effects
Conditioning, Operant / drug effects
Dose-Response Relationship, Drug
Excitatory Amino Acid Antagonists / administration & dosage,  pharmacology*
Injections, Intraperitoneal
Quinoxalines / administration & dosage,  pharmacology
Rats, Wistar
Receptors, AMPA / antagonists & inhibitors*
Receptors, Dopamine D1 / antagonists & inhibitors
Time Factors
Reg. No./Substance:
0/Benzazepines; 0/Excitatory Amino Acid Antagonists; 0/Quinoxalines; 0/Receptors, AMPA; 0/Receptors, Dopamine D1; 102771-26-6/GYKI 52466; 118876-58-7/2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; 12794-10-4/Benzodiazepines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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