| AMP-activated protein kinase and the regulation of Ca2+ signalling in O2-sensing cells. | |
| | |
MedLine Citation:
|
PMID: 16709639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
All cells respond to metabolic stress. However, a variety of specialized cells, commonly referred to as O2-sensing cells, are acutely sensitive to relatively small changes in PO2. Within a variety of organisms such O2-sensing cells have evolved as vital homeostatic mechanisms that monitor O2 supply and alter respiratory and circulatory function, as well as the capacity of the blood to transport O2. Thereby, arterial PO2 may be maintained within physiological limits. In mammals, for example, two key tissues that contribute to this process are the pulmonary arteries and the carotid bodies. Constriction of pulmonary arteries by hypoxia optimizes ventilation-perfusion matching in the lung, whilst carotid body excitation by hypoxia initiates corrective changes in breathing patterns via increased sensory afferent discharge to the brain stem. Despite extensive investigation, the precise mechanism(s) by which hypoxia mediates these responses has remained elusive. It is clear, however, that hypoxia inhibits mitochondrial function in O2-sensing cells over a range of PO2 that has no such effect on other cell types. This raised the possibility that AMP-activated protein kinase might function to couple mitochondrial oxidative phosphorylation to Ca2+ signalling mechanisms in O2-sensing cells and thereby underpin pulmonary artery constriction and carotid body excitation by hypoxia. Our recent investigations have provided significant evidence in support of this view. |
| | |
Authors:
|
A Mark Evans |
Related Documents
:
|
11219579 - Barley mla and rar mutants compromised in the hypersensitive cell death response agains... 11274089 - Induction of adrenomedullin by hypoxia in cultured retinal pigment epithelial cells. 16026709 - Cell line-dependent differences in uptake and retention of the hypoxia-selective nuclea... 8916219 - Thermotaxis of human trophoblastic cells. 8033899 - Generation of reactive-oxygen species induced by electropermeabilization of chinese ham... 10966869 - Oxygen: friend or foe? archaeal superoxide dismutases in the protection of intra- and e... 21903579 - P53 independent epigenetic repression of p21waf1 in t-cell acute lymphoblastic leukemia. 20967379 - Overview of single-cell analyses: microdevices and applications. 19100259 - Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes indep... |
Publication Detail:
|
Type: Journal Article; Review Date: 2006-05-18 |
Journal Detail:
|
Title: The Journal of physiology Volume: 574 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2006 Jul |
Date Detail:
|
Created Date: 2006-06-30 Completed Date: 2006-09-05 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
|
Languages: eng Pagination: 113-23 Citation Subset: IM |
Affiliation:
|
Division of Biomedical Sciences, School of Biology, Bute Building, University of St Andrews, St Andrews, Fife KY16 9TS, UK. ame3@st-andrews.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Calcium / metabolism* Calcium Signaling / physiology* Cell Hypoxia / physiology Energy Metabolism / physiology* Homeostasis / physiology* Humans Muscle, Smooth, Vascular / enzymology* Oxygen / metabolism* Protein Kinases / metabolism* |
| Chemical | |
Reg. No./Substance:
|
7440-70-2/Calcium; 7782-44-7/Oxygen; EC 2.7.-/Protein Kinases; EC 2.7.1.-/AMP-activated protein kinase kinase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of repetitive hypoxic apnoeas on baroreflex function in humans.
Next Document: Different responses of rat cerebellar Purkinje cells and Golgi cells evoked by widespread convergent...