Document Detail


AMP-activated protein kinase (AMPK) control of fatty acid and glucose metabolism in the ischemic heart.
MedLine Citation:
PMID:  12689619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myocardial ischemia is the leading cause of all cardiovascular deaths in North America. Myocardial ischemia is accompanied by profound changes in metabolism including alterations in glucose and fatty acid metabolism, increased uncoupling of glucose oxidation from glycolysis and accumulation of protons within the myocardium. These changes can contribute to a poor functional recovery of the heart. One key player in the ischemia-induced alteration in fatty acid and glucose metabolism is 5'AMP-activated protein kinase (AMPK). Accumulating evidence suggest that activation of AMPK during myocardial ischemia both increases glucose uptake and glycolysis while also increasing fatty acid oxidation during reperfusion. Gain-of-function mutations of AMPK in cardiac muscle may also be causally related to the development of hypertrophic cardiomyopathies. Therefore, a better understanding of role of AMPK in cardiac metabolism is necessary to appropriately modulate its activity as a potential therapeutic target in treating ischemia reperfusion injuries. This review attempts to update some of the recent findings that delineate various pathways through which AMPK regulates glucose and fatty acid metabolism in the ischemic myocardium.
Authors:
Nandakumar Sambandam; Gary D Lopaschuk
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in lipid research     Volume:  42     ISSN:  0163-7827     ISO Abbreviation:  Prog. Lipid Res.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-11     Completed Date:  2003-06-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7900832     Medline TA:  Prog Lipid Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  238-56     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Canada.
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MeSH Terms
Descriptor/Qualifier:
AMP-Activated Protein Kinases
Energy Metabolism
Fatty Acids / metabolism*
Glucose / metabolism*
Glycolysis
Humans
Multienzyme Complexes / genetics,  physiology*
Mutation
Myocardial Ischemia / metabolism*
Myocardial Reperfusion Injury / metabolism
Oxidation-Reduction
Protein-Serine-Threonine Kinases / genetics,  physiology*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Multienzyme Complexes; 50-99-7/Glucose; EC 2.7.11.1/AMP-Activated Protein Kinases; EC 2.7.11.1/Protein-Serine-Threonine Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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