Document Detail


AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases.
MedLine Citation:
PMID:  12805060     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute myeloid leukemia (AML) cases with 11q23 abnormalities involving the MLL gene comprise one category of recurring genetic abnormalities in the WHO classification. In an unselected series of 1897 AML cases, 54 patients with an 11q23/MLL rearrangement were identified, resulting in an incidence of 2.8%. The incidence of AML with MLL rearrangement was significantly higher in therapy-related AML (t-AML) than in de novo AML (9.4% vs 2.6%, P <.0001). The frequency of MLL rearrangements was significantly higher in patients younger than 60 years (5.3% vs 0.8%, P <.0001). While the incidence of MLL rearrangements in AML M4, M5a, and M5b was 4.7%, 33.3%, and 15.9%, respectively, it was found in only 0.9% of all other French-American-British (FAB) subtypes (P <.0001). Compared with AML with intermediate karyotype, AML with 11q23/MLL rearrangement had a worse outcome, which was rather comparable with AML with unfavorable karyotype. Compared with t-AML, the median overall survival (OS) of de novo AML with MLL rearrangement was significantly better (2.5 vs 10 months, P =.0143). No significant differences in median OS were observed between cases with t(9;11) compared with all other MLL rearrangements (10.0 vs 8.9 months, P =.36). In conclusion, the category AML with 11q23/MLL abnormalities accounts for 2.8% of unselected AML, is closely associated with monocytic differentiation, and has a dismal prognosis. (
Authors:
Claudia Schoch; Susanne Schnittger; Mirjam Klaus; Wolfgang Kern; Wolfgang Hiddemann; Torsten Haferlach
Publication Detail:
Type:  Journal Article     Date:  2003-06-12
Journal Detail:
Title:  Blood     Volume:  102     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-23     Completed Date:  2003-10-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2395-402     Citation Subset:  AIM; IM    
Affiliation:
Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistr 15, 81377 München, Germany. claudia.schoch@med3.med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Chromosome Aberrations*
Chromosomes, Human, Pair 11*
Cohort Studies
Follow-Up Studies
Gene Rearrangement
Humans
Incidence
Leukemia, Erythroblastic, Acute / genetics,  mortality,  pathology
Leukemia, Megakaryoblastic, Acute / genetics,  mortality,  pathology
Leukemia, Monocytic, Acute / genetics,  mortality,  pathology
Leukemia, Myeloid, Acute / genetics*,  mortality*,  pathology
Leukemia, Myelomonocytic, Acute / genetics,  mortality,  pathology
Leukemia, Promyelocytic, Acute / genetics,  mortality,  pathology
Middle Aged
Prognosis
Remission Induction
Survival Rate
World Health Organization

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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