Document Detail

AMI is associated with polymorphisms in the NOS3 and FGB but not in PAI-1 genes in young adults.
MedLine Citation:
PMID:  17126309     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We investigated the relationship between NOS3, FGB and PAI-1 polymorphisms and endothelial dysfunction and risk factors for acute myocardial infarction (AMI) in young adults. METHODS: Endothelial function was measured by response to flow mediated vasodilation (FMV) and induced by nitrate (FMN). Biochemical parameters were measured by standard enzymatic methods and plasma total nitrate was analyzed by the NOA system. NOS3 (T-786C, G894T and intron 4A/B STR), FGB (C-148T and G-455A) and PAI-1 (4G/5G) polymorphisms were determined by PCR-RFLP. RESULTS: Concentrations of total and LDL cholesterol, apo B, triglycerides, nitrate, PAI-1 and fibrinogen were higher and apo AI, HDL cholesterol and FMV were lower in AMI patients than in controls (p<0.001). PAI-1 (p<0.001) but not nitrate was higher in AMI patients with low response to FMV. NOS3 T-786C and FGB C-148T polymorphisms were associated with AMI (p<0.050). NOS3 T-786C was also related to hypertension (p=0.049). NOS3 intron 4A/B STR was associated with increased concentrations of total cholesterol and apo B. NOS3-786TT/894GT haplotype was associated with increased FMV (p=0.018) than the other haplotypes. CONCLUSIONS: Our data suggest NOS3 and FGB polymorphisms are associated with AMI. NOS3 is also related to hypertension, endothelial dysfunction and variation on serum cholesterol in young adults with AMI.
Marcelo Ferraz Sampaio; Mario Hiroyuki Hirata; Rosario Dominguez Crespo Hirata; Fabiana Cristina Pereira Santos; Raffaella Picciotti; André Ducati Luchessi; Sonia de Quateli Doi; Dikran Armaganijan; Michel Batlouni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-28
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  377     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2006-12-18     Completed Date:  2007-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  154-62     Citation Subset:  IM    
Instituto Dante Pazzanese de Cardiologia, Sao Paulo, SP, Brazil.
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MeSH Terms
Coronary Angiography
Fibrinogen / genetics*
Myocardial Infarction / drug therapy,  genetics*,  metabolism,  pathology
Nitrates / blood,  therapeutic use
Nitric Oxide Synthase Type III / genetics*,  metabolism
Plasminogen Activator Inhibitor 1 / genetics,  metabolism
Polymorphism, Genetic / genetics*
Regional Blood Flow
Risk Factors
Reg. No./Substance:
0/Nitrates; 0/Plasminogen Activator Inhibitor 1; 9001-32-5/Fibrinogen; EC protein, human; EC Oxide Synthase Type III

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