Document Detail

AM 251 differentially effects food-maintained responding depending on food palatability.
MedLine Citation:
PMID:  20331999     Owner:  NLM     Status:  MEDLINE    
Ligands functioning as antagonists and inverse agonists at the cannabinoid CB(1)-receptor (e.g., AM 251, AM 281, and rimonabant (previously identified as SR141716)) have been demonstrated to have effects on satiety, consumption of, and the motivation to work for, or obtain food. These represent behavioral effects that may also be linked to characteristics such as food palatability or motivation to obtain food. Given the recent removal of rimonabant from clinical trials, a thorough characterization of ingestive behaviors that are associated with other likely candidate drugs is warranted. In the present study, normal weight male Long Evans rats were trained to respond for grain or chocolate-flavored food pellets under progressive-ratio schedules of reinforcement. Rats received acute injections of the CB(1) receptor antagonist AM 251 (0.3-3.0 mg/kg) or vehicle prior to daily testing sessions. Administration of AM 251 produced significant dose-dependent reductions in responding for, deliveries of, and break points (BP) associated with chocolate-flavored but not grain pellets. These data add to the literature demonstrating the ability of CB(1) antagonists to selectively reduce motivation to obtain highly palatable reinforcers.
Suzanne M Droste; Samantha K Saland; Emily K Schlitter; Joshua S Rodefer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-21
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  95     ISSN:  1873-5177     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  443-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Department of Psychology, Florida State University, Tallahassee, FL 32306, USA.
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MeSH Terms
Animal Feed / analysis
Appetite Regulation / drug effects
Appetitive Behavior / drug effects*
Behavior, Animal / drug effects
Cannabinoids / antagonists & inhibitors
Conditioning, Operant
Dose-Response Relationship, Drug
Drug Inverse Agonism
Food Preferences*
Motivation / drug effects
Obesity / prevention & control
Piperidines / pharmacology*
Pyrazoles / pharmacology*
Random Allocation
Rats, Long-Evans
Receptor, Cannabinoid, CB1 / antagonists & inhibitors*
Reinforcement (Psychology)
Reg. No./Substance:
0/AM 251; 0/Cannabinoids; 0/Piperidines; 0/Pyrazoles; 0/Receptor, Cannabinoid, CB1

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