Document Detail

AM 251 and beta-Funaltrexamine reduce fat intake in a fat-preferring strain of mouse.
MedLine Citation:
PMID:  17475345     Owner:  NLM     Status:  MEDLINE    
This experiment aimed to examine the role of the CB1 and Opioid mu receptors on fat preference by administering the CB1 inverse agonist AM 251 (5mg/kg i.p.) and the opioid mu antagonist beta-Funaltrexamine (15mg/kg s.c.) for 4 days to fat-preferring C57BL/6 mice fed a two-choice high-fat/low-fat diet. Both drugs were found to significantly reduce total energy intake, high-fat diet intake and fat preference during treatment.
Timothy South; Chao Deng; Xu-Feng Huang
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Publication Detail:
Type:  Journal Article     Date:  2007-03-31
Journal Detail:
Title:  Behavioural brain research     Volume:  181     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-05-25     Completed Date:  2007-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  153-7     Citation Subset:  IM    
Neurobiology Research Centre for Metabolic and Psychiatric Disorders, School of Health Sciences, University of Wollongong, Northfields Avenue, NSW 2522, Australia.
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MeSH Terms
Analysis of Variance
Choice Behavior / drug effects
Dietary Fats / administration & dosage*
Eating / drug effects
Energy Intake / drug effects
Food Preferences / drug effects*
Mice, Inbred C57BL
Naltrexone / analogs & derivatives*,  pharmacology
Narcotic Antagonists / pharmacology*
Piperidines / pharmacology*
Pyrazoles / pharmacology*
Reg. No./Substance:
0/AM 251; 0/Dietary Fats; 0/Narcotic Antagonists; 0/Piperidines; 0/Pyrazoles; 16590-41-3/Naltrexone; 72782-05-9/beta-funaltrexamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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