| AM 251 and beta-Funaltrexamine reduce fat intake in a fat-preferring strain of mouse. | |
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MedLine Citation:
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PMID: 17475345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This experiment aimed to examine the role of the CB1 and Opioid mu receptors on fat preference by administering the CB1 inverse agonist AM 251 (5mg/kg i.p.) and the opioid mu antagonist beta-Funaltrexamine (15mg/kg s.c.) for 4 days to fat-preferring C57BL/6 mice fed a two-choice high-fat/low-fat diet. Both drugs were found to significantly reduce total energy intake, high-fat diet intake and fat preference during treatment. |
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Authors:
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Timothy South; Chao Deng; Xu-Feng Huang |
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Publication Detail:
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Type: Journal Article Date: 2007-03-31 |
Journal Detail:
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Title: Behavioural brain research Volume: 181 ISSN: 0166-4328 ISO Abbreviation: Behav. Brain Res. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-05-25 Completed Date: 2007-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 153-7 Citation Subset: IM |
Affiliation:
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Neurobiology Research Centre for Metabolic and Psychiatric Disorders, School of Health Sciences, University of Wollongong, Northfields Avenue, NSW 2522, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Choice Behavior / drug effects Dietary Fats / administration & dosage* Eating / drug effects Energy Intake / drug effects Food Preferences / drug effects* Male Mice Mice, Inbred C57BL Naltrexone / analogs & derivatives*, pharmacology Narcotic Antagonists / pharmacology* Phenotype Piperidines / pharmacology* Pyrazoles / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/AM 251; 0/Dietary Fats; 0/Narcotic Antagonists; 0/Piperidines; 0/Pyrazoles; 16590-41-3/Naltrexone; 72782-05-9/beta-funaltrexamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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