Document Detail


ALSOD: the Amyotrophic Lateral Sclerosis Online Database.
MedLine Citation:
PMID:  18608099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
More than 100 point mutations spanning the 153 amino acid SOD1 sequence have been identified in individuals with ALS. In 1999 the Amyotrophic Lateral Sclerosis Database (ALSOD) was generated to store these mutations along with ALS patient information to facilitate the identification of a correlation between the SOD1 genotype with the ALS phenotype. Here we report our ongoing development and redesign of the ALSOD database and its automated procedures. The significant new features have improved ALSOD, helping link the mutations of the SOD1 gene to the hypothetical three-dimensional protein structural rearrangement, and the resulting ALS phenotype. Additionally, ALSOD now provides a more comprehensive knowledge base for ALS, detailing genetic, proteomic, and bioinformatics information associated with the disease. ALSOD can be accessed at http://alsod.iop.kcl.ac.uk/als/.
Authors:
Richard Wroe; Amy Wai-Ling Butler; Peter M Andersen; John F Powell; Ammar Al-Chalabi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases     Volume:  9     ISSN:  1471-180X     ISO Abbreviation:  Amyotroph Lateral Scler     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-21     Completed Date:  2008-08-27     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  101283386     Medline TA:  Amyotroph Lateral Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  249-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amyotrophic Lateral Sclerosis / genetics*
Databases, Genetic*
Humans
Mutation*
Superoxide Dismutase / genetics*
Grant Support
ID/Acronym/Agency:
G0500289//Medical Research Council; G0600974//Medical Research Council; //Medical Research Council
Chemical
Reg. No./Substance:
EC 1.15.1.-/superoxide dismutase 1; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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